SLC39A8基因与新疆维吾尔族人群精神分裂症的关联性研究

发布时间：2018-03-05 03:32

本文选题：精神分裂症　切入点：SLC39A8基因　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨SLC39A8基因的单核苷酸多态性(single nucleotide polymorphism,SNP)与精神分裂症的发病是否相关。方法:研究对象来自新疆地区的维吾尔族人群。采用病例-对照研究(case-control study),纳入985例维吾尔族精神分裂症(Schizophrenia,SC)患者及1218例维吾尔族非精神分裂症对照。测定两组的SLC39A8基因rs13107325位点的基因型。结果:SLC39A8基因rs13107325位点多态性与精神分裂症的发病有关(P_(allele)=0.018,P_(genotype)=0.0004,odds ratio(OR)=1.310,95%CI=1.048-1.650),其中基因型C/T(P=0.735,OR=0.958,95%CI=0.757-1.241)和基因型C/C(P=0.261,OR=0.981,95%CI=0.949-1.014)与精神分裂症发病无关;等位基因C(P=0.018,OR=0.760,95%CI=0.604-0.955)与精神分裂症的发病成负关联;而基因型T/T(P=0.0004,OR=4.28,95%CI=1.913-9.186)和等位基因T(P=0.018,OR=1.310,95%CI=1.044-1.594)则与精神分裂症的发病成正关联,为精神分裂症发病的危险因素。结论:在中国新疆维吾尔族人群中,SLC39A8基因rs13107325位点可能增加新疆维吾尔族人群精神分裂症的易感性。
[Abstract]:Objective: to investigate whether the single nucleotide polymorphism (SNP) of SLC39A8 gene is associated with the onset of schizophrenia. Methods: a case-control study was conducted to study the incidence of schizophrenia in Uygur ethnic groups from Xinjiang. A case-control study was conducted to include 985 cases of Uygur. The genotypes of rs13107325 locus of SLC39A8 gene in two groups were determined. Results the polymorphism of rs13107325 locus of SLC39A8 gene was associated with the onset of schizophrenia. Results the incidence of schizophrenia was related to the incidence of schizophrenia. There was a correlation between the polymorphism of the rs13107325 locus of the SLC39A8 gene and the incidence of schizophrenia. There was a correlation between the polymorphism of the rs13107325 locus of the SLC39A8 gene and the incidence of schizophrenia. There was a correlation between the polymorphism of the rs13107325 locus of the SLC39A8 gene and the incidence of schizophrenia. There was no correlation between the incidence of schizophrenia and the genotype C / P 0.261 (0.981C 0.981C ~ 0.949-1.014), which were related to the incidence of schizophrenia. The results showed that the incidence of schizophrenia was not related to the type of C / T / T / P 0.735 / 0.735 / 0.75 ~ 1.241) and the genotype of C / P _ (0.261) was 0.981C ~ (0.949 ~ 1.014). There was a negative correlation between the genotype T / T / T 0.0004 and 1.913-9.186) and the OR1.31095CI1.044-1.594) and the genotype T / T ~ (0.0004) was positively associated with the onset of schizophrenia, while the genotype T / T ~ (0.0004) and the allele T / T ~ (0.018) OR1.310 95CII 1.044-1.594) were positively associated with the onset of schizophrenia, while the genotype T / T ~ (0.0004) OR1.913-9.186) was positively associated with the onset of schizophrenia. Conclusion: the rs13107325 locus of SLC39A8 gene in Xinjiang Uygur population may increase the susceptibility to schizophrenia in Xinjiang Uygur population.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.3

【参考文献】