精神分裂症患者纤溶酶原激活物抑制物-1基因多态性分析

发布时间：2018-03-07 21:37

本文选题：基因多态性　切入点：精神分裂症　出处：《广东医学》2017年15期 　论文类型：期刊论文

【摘要】：目的探讨纤溶酶原激活物抑制物-1(PAI-1)基因4G/5G多态性在汉族精神分裂症患者中的分布情况,初步判断该基因多态性是否与精神分裂症患者好发缺血性心脏病相关。方法选取汉族精神分裂症患者178例为SCZ组,健康个体182例为对照组,应用等位基因特异性PCR的方法了解各组PAI-1基因4G/5G多态性情况。结果 SCZ组与对照组在4G/4G、4G/5G和5G/5G基因型分布差异有统计学意义,SCZ组的4G/4G基因型频率高于对照组(P0.05);SCZ组的4G型基因频率高于对照组(P0.05)。结论精神分裂症患者PAI-1基因启动子区4G型基因和4G/4G基因型的频率高于常人,4G型基因频率是精神分裂症的危险因素,也是导致精神分裂症患者好发缺血性心脏病的一个可能原因。
[Abstract]:Objective to investigate the distribution of 4G / 5G polymorphism of plasminogen activator inhibitor (PAI-1) gene in Chinese patients with schizophrenia. Methods 178 patients with schizophrenia in Han nationality were selected as SCZ group and 182 healthy individuals as control group. Results the distribution of 4G / 5G and 5G / 5G genotypes in 4G / 4G / 5G and 5G / 5G were significantly different between SCZ group and control group. The frequency of 4G / 4G genotype in SCZ group was higher than that in control group (P 0.05). Conclusion the frequency of 4G gene and 4G / 4G genotype in the promoter region of PAI-1 gene in schizophrenic patients is higher than that in normal controls, which is the risk factor of schizophrenia. It is also a possible cause of ischemic heart disease in patients with schizophrenia.
【作者单位】：暨南大学附属第一医院精神心理科;广东医科大学附属医院临床医学研究中心;湛江市第三人民医院二科;中国人民解放军第422医院精神科;广东省国营湖光农场医院精神科;广东三九脑科医院心理行为医学科睡眠医学中心;
【分类号】：R749.3

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