COMT基因Val158Met多态性与同伴关系对青少年抑郁的影响

发布时间：2018-03-12 12:51

本文选题：青少年　切入点：抑郁　出处：《心理发展与教育》2017年02期 　论文类型：期刊论文

【摘要】：以1048名汉族青少年为被试,采用问卷法和基因分型技术,综合运用传统回归分析和新兴的再参数化回归分析,考察COMT基因Val158Met多态性与同伴关系对青少年抑郁的交互作用模式及其性别差异。结果发现,COMT基因与同伴接纳和同伴拒绝交互预测青少年抑郁,具体表现为,在低同伴接纳或高同伴拒绝环境中,携带ValVal基因型的青少年抑郁水平高于Met等位基因携带者;在高同伴接纳或低同伴拒绝环境中,携带ValVal基因型的青少年抑郁水平低于Met等位基因携带者。此外,COMT基因与同伴接纳和同伴拒绝的交互作用与男生抑郁的关联更加密切。结果显示,COMT基因与同伴关系的交互效应为不同易感性模型提供了证据,而且该基因×环境交互效应存在性别差异。
[Abstract]:A total of 1048 adolescents of Han nationality were enrolled in the study. Traditional regression analysis and new re-parameterized regression analysis were used by questionnaire and genotyping techniques. To investigate the interaction pattern of COMT gene Val158Met polymorphism and peer relationship on adolescent depression and their gender differences, we found that cocomt gene and peer acceptance and peer rejection interactively predict adolescent depression. In low peer acceptance or high peer rejection environments, depression levels in adolescents with ValVal genotype were higher than those in Met allele carriers, and in high peer acceptance or low peer rejection environments, The depression level of adolescents with ValVal genotype was lower than that of Met allele carriers. In addition, the interaction between ValVal gene and peer acceptance and peer rejection was more closely related to male depression. Provides evidence for different susceptibility models. Moreover, there were gender differences in the interaction effect of the gene and environment.
【作者单位】：山东师范大学心理学院;美国Lewis
【基金】：国家自然科学基金项目(31271105、31671156) 山东省自然科学基金项目(ZR2014CQ030) 高等学校博士学科点专项科研基金项目(博导类20133704110001)
【分类号】：B842.6

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