脂联素基因多态性与南京汉族高血压脑出血易感性关系研究

发布时间：2018-03-13 10:55

本文选题：高血压脑出血　切入点：脂联素基因　出处：《南京医科大学学报(自然科学版)》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨人血脂联素(adiponectin,APN)基因单核苷酸多态性与中国南京地区人群高血压脑出血(hypertensive intracerebral hemorrhage,HICH)的相关性。方法:利用SNa Pshot法检测APN中rs2241766、rs1501299、rs17300539和rs266729的基因型及等位基因在150例HICH患者及150例正常健康人中的分布特征。结果:1rs266729位点的GG基因型和G等位基因在病例组和对照组的分布频率具有明显统计学差异(P0.05);2rs266729位点的GG基因型的HICH病危险度是CC基因型的2.623倍(95%CI:1.282~5.366;P=0.008),校正后仍为HICH的危险因素;3rs2241766、rs1501299、rs17300539位点与HICH的发病风险均没有关联。结论:ADIPOQ基因的rs266729基因多态性与南京地区汉族人群HICH的易感性相关;rs266729位点的GG基因型和G等位基因可能增加南京地区汉族人群HICH的发病风险。
[Abstract]:Objective: to investigate the association of single nucleotide polymorphism of human adiponectin (APN) gene with HICH in hypertensive intracerebral hemorrhage in Nanjing area of China. Methods: the genotypes and alleles of rs2241766rs1501299rs17300539 and rs266729 in APN were detected by SNa Pshot in 150 patients with hypertensive intracerebral hemorrhage. Results the distribution frequency of GG genotype and G allele at 1 rs266729 locus was significantly different between the case group and the control group. The HICH risk of the GG genotype at the GG locus of P0.05S266729 was significantly different from that of the control group. It is 2.623 times as high as the CC genotype and 95 times as high as that of the CC genotype. There is no association between the rs266729 polymorphism of the rs266729 gene of the gene and the susceptibility to HICH of the Han population in Nanjing, which is the risk factor of 3rs2241766 / rs1501299rs17300539 and the susceptibility to HICH of the Han population in Nanjing. Conclusion the genetic polymorphisms of the rs266729 gene of the gene are related to the susceptibility to HICH in the Han population in Nanjing area, and there is no association between the polymorphism of the rs266729 gene of the gene and the GG base of the HICH locus rs266729 of the Han nationality population in Nanjing. Genotype G and allele G may increase the risk of HICH in Nanjing Han population.
【作者单位】：南通大学附属南京江北人民医院神经外科;东南大学附属中大医院神经外科;金华市中心医院神经外科;
【基金】：江苏省自然科学基金资助(BK2010419)
【分类号】：R544.1;R743.34

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