孕鼠补充苏氨酸锌对仔鼠生长及其相关基因表达的影响

发布时间：2018-03-13 12:47

本文选题：苏氨酸锌　切入点：锌转运体Zn　出处：《食品科学》2017年05期 　论文类型：期刊论文

【摘要】：为研究母体补充苏氨酸锌对子代生长水平的影响,实验将40只受孕SD大鼠随机分为5组,于孕鼠妊娠期第6~15天分别灌胃补充高、中、低剂量苏氨酸锌(灌胃剂量分别为250、500、1 000 mg/(kg·d)),孕鼠分娩后将仔鼠常规饲养,并测量1月龄仔鼠的生长指标和相关基因的表达。结果表明,苏氨酸锌各剂量组仔鼠体质量与对照组相比有显著提高(P0.05);苏氨酸锌各剂量组与对照组相比较,其组织中锌转运体Zn T1基因的相对表达量都有显著提高(P0.05);苏氨酸锌高剂量组与对照组相比较,其组织中胰岛素样生长因子IGF1基因相对表达量都有显著提高(P0.05);且胰岛素样生长因子受体基因IGF1R的表达与IGF1的表达趋势基本保持一致。实验说明妊娠期补充苏氨酸锌能在一定程度上提升仔鼠的生长性能,能显著提高仔鼠锌转运体Zn T1、胰岛素样生长因子IGF1及其受体IGF1R基因表达水平。
[Abstract]:Effects of supplemental zinc threonine offspring growth level of maternal, experiment 40 pregnant SD rats were randomly divided into 5 groups, in the first 6~15 days of pregnancy in pregnant rats were orally supplemented, high, low dose zinc threonine (gavage dose was 250500,1 000 mg/ (kg - D), delivery) pregnant rats after routine feeding rats, the expression of growth index and measurement of 1 month old rats and related genes. The results showed that zinc threonine body mass in each dose group rats compared with the control group significantly increased (P0.05); zinc threonine in each dose group compared with the control group, the relative zinc transporter Zn T1 gene the expression amount are significantly increased (P0.05); zinc threonine in high dose group compared with the control group, insulin-like growth factor IGF1 gene in the tissue expression are significantly increased (P0.05); and the insulin-like growth factor receptor gene expression of IGF1 and IGF1R of the table The trend is basically the same. Experiments show that supplementation of threonine zinc during pregnancy can improve the growth performance of offspring rats to a certain extent, and significantly increase the expression level of Zn T1, insulin-like growth factor IGF1 and its receptor IGF1R in offspring rats.

【作者单位】：南昌大学食品科学与技术国家重点实验室;
【基金】：江西省科技支撑计划项目(20151BBF60040) 江西省自然科学基金项目(20132BAB204002) 江西省重大科技创新研究项目(20124ACF00400) 江西省教育厅2011年度产学研合作项目(GJJ11002)
【分类号】：R153.1

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