PTPN22 C1858T基因多态性与系统性红斑狼疮易感性的Meta分析

发布时间：2018-03-18 05:01

本文选题：PTPN22　切入点：C1858T　出处：《华中科技大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:应用Meta分析系统评价PTPN22 C1858T基因多态性与系统性红斑狼疮的易感性之间的关系,以及其与狼疮性肾炎之间的关系。方法:计算机检索Pubmed、Embase、中国知网(CNKI)、万方数据库、CBMDisc,检索截止日期为2016年2月17日,全面收集国内外发表的关于PTPN22 C1858T基因多态性与系统性红斑狼疮的流行病学文献。严格按照所制定的纳入/排除标准筛选文献,并对符合纳入标准的文献进行数据提取,采用NOS标准(The Newcastle-Ottawa Scale)评价纳入文献的质量。应用STATA 12.0软件对提取的数据进行Meta分析,采取比值比(Odds ratio,OR)和95%CI可信区间(confidence interval,CI)作为合并效应量评价PTPN22 C1858T与SLE易感性之间关系的关联强度,通过Begg’s漏斗图和Egger直线回归法评估发表偏倚。敏感性分析采用逐个排除研究的方法评价结果的稳定性。结果:共纳入16个研究,包括3143例SLE患者,6980例对照,5种遗传模型Meta分析结果均显示PTPN22 C1858T基因多态性与SLE易感性相关(等位基因模型OR=1.64,95%CI=1.41-1.91;显性遗传模型OR=1.60,95%CI=1.42-1.81;隐性遗传模型OR=2.03,95%CI=1.35-3.05;纯合子模型OR=2.20,95%CI=1.46-3.32;杂合子模型OR=1.57,95%CI=1.39-1.77)。基于种族的亚组分析发现,PTPN22 C1858T基因多态性与欧洲人、西班牙人、阿拉伯人的SLE易感性相关;而未有证据显示与亚洲人群相关。该基因多态性与SLE合并狼疮性肾炎的相关性分析显示PTPN22 C1858T基因多态性可能与系统性红斑狼疮患者并发狼疮性肾炎的危险性相关(显性遗传模型:OR=1.65,95%CI=1.19-2.30)。结论:PTPN22 C1858T基因多态性与系统性红斑狼疮的易感性有关;PTPN22 C1858T基因多态性可能与系统性红斑狼疮患者并发狼疮性肾炎的危险性相关。
[Abstract]:Objective: to evaluate the relationship between PTPN22 C1858T gene polymorphism and susceptibility to systemic lupus erythematosus by Meta analysis system. Methods: Pubmed Embase, CNKI and CBM Disc were searched by computer, and the deadline of search was February 17th 2016. To collect the epidemiological literature about PTPN22 C1858T gene polymorphism and systemic lupus erythematosus published at home and abroad. The NOS standard was used to evaluate the quality of the Newcastle-Ottawa scale. The Meta analysis of the extracted data was carried out by using STATA 12.0 software, and the ratio ratio of odds ratio (OR) and 95CI confidence confidence interval-cience were used as the combined effects to evaluate the correlation between PTPN22 C1858T and SLE susceptibility, and the correlation between PTPN22 C1858T and SLE susceptibility was evaluated by using STATA 12.0 software. The bias of publication was evaluated by Begg's funnel graph and Egger linear regression. Sensitivity analysis was used to evaluate the stability of the results by one exclusion study. Results: a total of 16 studies were included. The results of Meta analysis of 5 genetic models including 3 143 SLE patients and 6 980 controls showed that the polymorphism of PTPN22 C1858T gene was associated with the susceptibility to SLE (allelic model OR1. 644 / 95 CI 1.41-1.91; dominant genetic model OR1. 6095CII 1.42-1.81; recessive genetic model OR2.039 95CII 1.35-3.05; homozygote model OR1. 20995 CI1.46-3.32; heterozygote model OR2.20995 CI1.46-3.32; dominant genetic model OR1. 6095CI1: 1.42-1.81; recessive genetic model OR2.039 95CI1. 35-3.05; homozygous model OR2.209595 CI1.46-3.32; The Race based subgroup analysis showed that the polymorphism of PTPN22 C1858T gene was associated with that of Europeans. The SLE susceptibility of Spaniards and Arabs was related; There is no evidence of association with Asian population. The association between the polymorphism of the gene and SLE with lupus nephritis suggests that the polymorphism of PTPN22 C1858T gene may be associated with the risk of lupus nephritis in patients with systemic lupus erythematosus. (dominant genetic model: OR1.165 / 95) 1.19-2.300.Conclusion the polymorphism of the 1: PTPN22 C1858T gene is associated with the susceptibility of systemic lupus erythematosus to systemic lupus erythematosus. The polymorphism of PTPN22 C1858T gene may be associated with the risk of lupus nephritis in patients with systemic lupus erythematosus.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R593.241

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