通过网织血小板及JAK2V617F基因突变对原发性血小板增多症评估血栓发生率的研究

发布时间：2018-03-21 00:57

本文选题：原发性血小板增多症　切入点：网织血小板　出处：《世界最新医学信息文摘》2016年72期 　论文类型：期刊论文

【摘要】：目的探究网织血小板及JAK2V617基因突变检测对于原发性血小板增多症(ET)评估血栓发生率;方法在ET患者中用SY Sysmex XE-5000血细胞分析仪及配套原装试剂测定网织血小板,用RT-PCR测定JAK2V617基因突变,通过对网织血小板及JAK2V617基因突变检测对原发性血小板增多症中血栓发生率进行评估;结果 c2检验分析,P0.05,差异有统计学意义,可以认为网织血小板与血栓有正相关关系、JAK2基因突变与血栓存在正相关关系;Logistics回归分析显示JAK2V617基因突变阳性,血栓发生事件OR(odds ratio,比值比)为4.453,P0.05;网织血小板升高,血栓发生事件OR为4.400,P0.05。两项因素OR均大于1,表明其均使血栓发生危险性增高,两者均是血栓升高的独立危险因素。结论网织血小板数值升高、JAK2V617基因突变阳性与ET患者发生血栓率成正比,JAK2基因突变及网织血小板成为评估血栓早期发生的检查手段。
[Abstract]:Objective to evaluate the incidence of thrombus in patients with idiopathic thrombocytosis by reticulocyte and JAK2V617 gene mutation. The incidence of thrombus in patients with idiopathic thrombocytosis was evaluated by RT-PCR, reticulocyte and JAK2V617 gene mutation. It can be concluded that there is a positive correlation between reticulocyte and thrombus. The positive correlation between JAK2 gene mutation and thrombus was found by logistic regression analysis. The positive rate of JAK2V617 gene mutation and the ratio ratio of OR(odds to thrombogenesis were 4.453p0.05. reticulocyte increased. The OR of thrombogenesis events was 4.400 p 0.05.The OR of both factors was greater than 1, which indicated that both factors increased the risk of thrombosis. Conclusion the positive mutation of JAK2V617 gene is directly proportional to the incidence of thrombus in patients with et.
【作者单位】：吉林市中心医院血液科吉林市北华大学;
【分类号】：R733.3

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