同源异型盒基因10蛋白在大肠腺癌中的表达及其临床意义

发布时间：2018-03-26 19:18

本文选题：大肠癌　切入点：免疫组织化学　出处：《实用医学杂志》2017年19期

【摘要】：目的探讨大肠癌和正常大肠黏膜组织中同源异型盒基因10(HOXD10)的表达情况并探讨其临床意义。方法应用SP免疫组化法检测53例经4%中性甲醛固定和石蜡包埋的大肠癌及53例正常大肠黏膜组织标本中HOXD10蛋白的表达情况,并分析其与大肠癌患者临床病理参数间的关系。结果HOXD10蛋白在正常大肠黏膜组织中的阳性染色率(5.7%)明显低于大肠癌组织(64.2%),两者间差异有统计学意义(P0.05)。在大肠癌组织中,HOXD10蛋白染色阳性率在高分化(53.8%)、T1+T2(38.5%)、Ⅰ+Ⅱ期(54.3%)、无淋巴结转移(55.3%)均低于在低分化(73.0%)、T3+T4(72.5%)、Ⅲ+Ⅳ期(83.3%)、有淋巴结转移(86.7%),差异均有统计学意义(均P0.05),但HOXD10蛋白的染色阳性率与大肠癌患者的性别、年龄、癌灶原发部位及癌灶大小无相关性(均P0.05)。结论 HOXD10蛋白的表达与人大肠癌浸润和转移存在密切相关。
[Abstract]:Objective to investigate the expression and clinical significance of homologous cassette gene 10 (HOXD10) in colorectal carcinoma and normal colorectal mucosa. Methods SP immunohistochemical method was used to detect 53 cases of colorectal cancer with 4% neutral formaldehyde fixation and paraffin embedding. The expression of HOXD10 protein in 53 cases of normal colorectal mucosa. Results the positive staining rate of HOXD10 protein in normal colorectal mucosa was significantly lower than that in colorectal carcinoma tissue (P 0.05). The positive rate of HOXD10 protein staining in well-differentiated 53.8T _ 1 T _ (2) T _ (2) and T _ (2) T _ (2) and T _ (2) T _ (2) T _ (3) T _ (2) T _ (3) T _ (2) T _ (2) T _ (3) T _ (2) T _ (3) T _ (2) T _ (3) T _ (3) T _ (2) T _ (2) T _ (3) T _ (2) T _ (2) T _ (2) and T _ (3) T _ (2) T _ (3) T _ (3) T _ (2) and T _ (3) T _ (3) T. Rate and sex of colorectal cancer patients, There was no correlation among age, primary location and tumor size (all P0.050.Conclusion the expression of HOXD10 protein is closely related to the invasion and metastasis of human colorectal carcinoma.
【作者单位】：温州医科大学附属第三医院肿瘤外科;
【基金】：温州市科技计划项目(编号:Y20140384)
【分类号】：R735.34

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