朝鲜族人群脂联素基因单核苷酸多态性与多种代谢异常的相关性

发布时间：2018-03-30 09:24

本文选题：脂联素　切入点：单核苷酸多态性　出处：《延边大学医学学报》2016年03期

【摘要】：[目的]探讨朝鲜族人群脂联素基因4个位点单核苷酸多态性(SNPs)与多种代谢异常的相关性.[方法]选择延边农村地区朝鲜族人群400人作为研究对象,按照《中国血脂异常防治指南》中的代谢综合征(MS)诊断标准筛选出多种代谢异常患者.采用试剂盒提取外周全血DNA组,利用PCR-RFLP技术检测脂联素基因SNP+45,SNP+276,SNP-11377,SNP-11391的基因型.[结果]多因素逐步Logistic回归分析结果显示,SNP+45位点基因型与中心性肥胖和高血压具有相关性,OR值分别为1.773和2.150;SNP+276位点基因型与血脂异常和MS具有相关性,OR值分别为2.009和2.031;SNP-11377位点基因型与胰岛素抵抗(IR)、血脂异常及MS具有相关性,OR值分别为1.095,2.606和2.097;SNP-11391位点基因型与IR、中心性肥胖、高血压、MS和血脂异常具有相关性,OR值分别为1.710,1.723,1.906,2.028和2.128.[结论]延边地区朝鲜族人群脂联素基因4个位点SNPs的不同代谢异常患病易感性程度有所不同.
[Abstract]:[objective] to investigate the association between adiponectin gene SNPs at four loci and metabolic abnormalities in Korean population. [methods] 400 Korean population in rural areas of Yanbian were selected as study subjects. According to the diagnostic criteria of metabolic syndrome (MS) in the guide to the prevention and treatment of dyslipidemia in China, a variety of patients with abnormal metabolism were selected. The peripheral blood DNA group was extracted by kit. Genotypes of adiponectin gene SNP 45-SNP276SP-11377-SNP-11391 were detected by PCR-RFLP technique. [results] the multivariate stepwise Logistic regression analysis showed that the genotype of SNP45 was associated with central obesity and hypertension. The OR values were 1.773 and 2.150g SNP276, respectively. The OR values of genotype and MS were 2.009 and 2.031 ~ (-1) ~ SNP-11377, respectively. The OR values of genotype and MS were 1.095 ~ 2.606 and 2.097 ~ (-1) ~ (-1) ~ 11391, respectively. The OR values of MS and dyslipidemia were 1.710 (1.723) 1.906 (2.028) and 2.128 (respectively). [conclusion] the susceptibility of 4 SNPs loci of adiponectin gene was different in Yanbian area.
【作者单位】：延边大学附属医院;延边大学医学院;
【基金】：国家自然科学基金项目(30860244,81260138) 吉林省教育厅基金项目(2013-26)
【分类号】：R589

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