ADD1基因Gly460Trp多态性与原发性高血压发病相关性的Meta分析

发布时间：2018-04-03 04:26

  本文选题：ADD　切入点：基因多态性　出处：《中国循证心血管医学杂志》2016年06期

【摘要】：目的系统评价ADD1基因Gly460Trp多态性与原发性高血压发病风险的相关性。方法查计算机检索Pub Med、Embase、CBM、VIP、Wanfang Data和CNKI,查找关于ADD1基因Gly460Trp多态性与原发性高血压发病相关性的病例对照研究,检索时限均为各数据库建库至2015年8月。由两名评价员同时进行文献筛选及资料提取,采用Stata 12.0软件进行Meta分析。结果共纳入文献43篇,包括12 309例原发性高血压患者,13 833例对照。Meta分析结果显示,ADD1基因Gly460Trp多态性与原发性高血压之间的相关性在等位基因模型(T vs.G:OR=1.10,95%CI:1.03~1.17)、显性基因模型(TT+GT vs.GG:OR=1.10,95%CI:1.00~1.20)、隐性基因模型(TT vs.GG+GT:OR=1.17,95%CI:1.07~1.29)和纯合子模型(TT vs.GG:OR=1.20,95%CI:1.06~1.35)中有统计学意义,尤其是在亚洲人群中。结论本Meta分析表明,ADD1基因Gly460Trp位点多态性与原发性高血压发病风险有相关性,尤其是亚洲人群。
[Abstract]:Objective to evaluate the association of ADD1 gene Gly460Trp polymorphism with the risk of essential hypertension.Methods the Data and CNKI of Pub Medbase were searched by computer, and the correlation between Gly460Trp polymorphism of ADD1 gene and the incidence of essential hypertension was searched. The time limit of searching for each database was to August 2015.Literature screening and data extraction were carried out by two evaluators at the same time. Meta analysis was carried out by Stata 12.0 software.Results 43 papers were included.鍖呮嫭12 309渚嬪師鍙戞，

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