质粒介导的黏菌素耐药基因mcr-1研究进展

发布时间：2018-04-10 14:44

本文选题：质粒 + 黏菌素　；参考：《遗传》2017年02期

【摘要】：mcr-1基因是迄今为止国际上首次发现的质粒介导的黏菌素耐药基因,可介导肠杆菌科细菌对多粘菌素类药物产生耐药并可通过质粒进行水平转移。最新研究表明该基因已通过Inc I2、Inc X4和Inc HI2等流行性质粒以及可移动元件,在全球35个不同国家和地区的人、动物和环境源多种肠杆菌中广泛传播。这些研究对于深入了解mcr-1基因介导的黏菌素耐药和传播机制、全球流行分布特征奠定了基础,丰富了耐药性形成理论。文章主要介绍了不同来源肠杆菌科细菌中mcr-1的分布流行情况、耐药和传播机制、基因环境等方面的研究进展,探讨了其临床风险性以及后续应对措施,以期为相关科研人员和临床工作者提供参考,共同应对抗生素耐药日益严峻的局面。
[Abstract]:Mcr-1 gene is the first plasmide-mediated myxin resistance gene found in the world. It can mediate the resistance of Enterobacteriaceae to polymyxin drugs and can be transferred horizontally through plasmids.New research shows that the gene has been widely distributed in 35 different countries and regions, including human, animal and environmental sources, through epidemic plasmids such as Inc I2N Inc. X4 and Inc HI2, as well as mobile elements.These studies have laid a foundation for further understanding of the mechanism of drug resistance and transmission of myxin mediated by mcr-1 gene and the characteristics of global epidemic distribution and enriched the theory of drug resistance formation.In this paper, the distribution and prevalence of mcr-1 in Enterobacteriaceae from different sources, the mechanism of drug resistance and transmission, the gene environment and so on were introduced, and the clinical risk and follow-up measures were discussed.In order to provide reference for related researchers and clinical workers to deal with the increasingly serious situation of antibiotic resistance.
【作者单位】：华南农业大学兽医学院;
【基金】：国家重点基础研究发展计划(973项目)(No.2013CB127200) 国际(地区)合作与交流项目(No.81661138002)资助~~
【分类号】：R440

【参考文献】