HMGB1基因3个多态位点与汉族群体乳腺癌易感性的关联

发布时间：2018-04-21 19:56

本文选题：乳腺癌 + HMGB　；参考：《基因组学与应用生物学》2017年08期

【摘要】：为了探讨HMGB1基因rs2249825、rs1412125和rs1045411的多态性与汉族女性乳腺癌易感性的关联性,本研究应用聚合酶链式反应-连接酶反应技术检测524例乳腺癌和518例正常对照组。我们发现rs2249825、rs1412125和rs1045411位点的等位基因频率和基因型分布在两组间比较无显著性差异(p0.05),单倍型C-T-A的分布频率在两组间具有显著性差异(11.80%vs 8.96%,p=0.045),校正混杂因素后该单倍型对乳腺癌的风险预测值为1.37(95%CI:0.97-1.93)。研究表明HMGB1基因的rs2249825、rs1412125和rs1045411位点多态性可能与乳腺癌的发病风险无关,所构成的单倍型C-T-A与乳腺癌患病的风险性具有潜在的关联性。本研究所得数据为本地区群体的乳腺癌易感基因的筛选以及评估易感基因对患病的风险程度提供参考数据,为乳腺癌的防治、诊断和个体化治疗研究提供了帮助。
[Abstract]:To investigate the association between the polymorphism of HMGB1 gene rs2249825 rs1412125 and the susceptibility of Han women to breast cancer, the polymerase chain reaction-ligase reaction technique was used to detect 524 cases of breast cancer and 518 cases of normal controls. We found that there was no significant difference in allele frequency and genotype distribution of rs2249825 rs1412125 and rs1045411 locus between the two groups. Haplotype C-T-A distribution frequency was significantly different between the two groups (11.80 vs 8.96p0.045). After adjusting for the confounding factors, the haplotype had a positive effect on breast milk. The predicted risk value for adenocarcinoma was 1.37- 95 CI: 0.97-1.93. The results showed that the rs2249825 rs1412125 and rs1045411 polymorphism of HMGB1 gene may not be associated with the risk of breast cancer, and the haplotype C-T-A is potentially associated with the risk of breast cancer. The data provided reference data for the screening of breast cancer susceptibility genes and the assessment of the risk of breast cancer in the population of our region, and also for the prevention and treatment, diagnosis and individualized treatment of breast cancer.
【作者单位】：齐齐哈尔医学院生物遗传教研室;齐齐哈尔市建华医院;大庆油田总医院普外科;齐齐哈尔医学院生物化学教研室;
【基金】：黑龙江省教育厅科学技术研究项目(12541903)资助
【分类号】：R737.9

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