老年原发性血小板增多症患者Jak2基因v617f点突变检测的临床意义

发布时间：2018-04-22 08:10

  本文选题：原发性血小板增多症 + Jak　； 参考：《中国老年学杂志》2017年18期

【摘要】：目的探讨老年原发性血小板增多症(ET)患者Jak2基因v617f点突变检测的临床意义。方法老年ET患者100例,检测Jak2基因v617f点突变,根据检测结果分为阴性组(n=54)与阳性组(n=46),比较两组年龄、性别、脾肿大、骨髓巨核细胞数、实验室检查指标及血栓发生率、出血率。结果两组年龄、性别、脾肿大及骨髓巨核细胞数差异均无统计学意义(均P0.05)。阳性组白细胞计数(WBC)水平显著高于阴性组(P0.05),两组血红蛋白(HGB)、血小板计数(PLT)水平比较差异无统计学意义(P0.05)。阳性组血栓发生率显著高于阴性组(P0.05),两组出血率比较差异无统计学意义(P0.05)。结论 Jak2基因v617f点突变检测有利于辅助临床诊断老年ET,有效评估患者疾病状态,并为临床治疗和预防血栓的发生提供参考依据。
[Abstract]:Objective to investigate the clinical significance of Jak2 v617 f point mutation in elderly patients with idiopathic thrombocytopenia. Methods the point mutation of Jak2 gene v617f was detected in 100 elderly patients with et. The results were divided into negative group (n = 54) and positive group (n = 46). The age, sex, splenomegaly, bone marrow megakaryocyte number, laboratory examination index, thrombosis rate and bleeding rate were compared between the two groups. Results there was no significant difference in age, sex, splenomegaly and the number of bone marrow megakaryocytes between the two groups (P 0.05). The level of WBCC in the positive group was significantly higher than that in the negative group (P 0.05), but there was no significant difference between the two groups in the levels of HGB and PLT (P 0.05). The incidence of thrombus in the positive group was significantly higher than that in the negative group (P 0.05). There was no significant difference in the bleeding rate between the two groups. Conclusion the detection of v617f point mutation of Jak2 gene is helpful for the diagnosis of senile ETS, the evaluation of disease status, and the reference for clinical treatment and prevention of thrombus.
【作者单位】： 惠州市中心人民医院血液科;
【基金】：惠州市科技计划项目(No.20160801)
【分类号】：R558.3
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本文编号：1786321