SSRP1表达对乳腺癌预后的影响及其基因集富集分析

发布时间：2018-04-22 19:57

本文选题：乳腺癌 + SSRP　；参考：《武汉大学学报(医学版)》2016年03期

【摘要】：目的:探讨SSRP1和乳腺癌的临床病理特征的关系;评价SSRP1对乳腺癌患者预后评价的意义;预测SSRP1影响乳腺癌进展的方式。方法:收集NCBI的基因表达汇编(GEO)中的编码基因表达谱数据集,对乳腺癌肿瘤样本表达谱资料及其对应的临床信息进行病理指标的回顾性分析(卡方检验)和预后分析(Kaplan-Meier法);利用GSEA方法分析预测SSRP1高表达样本中富集的基因集。结果:在乳腺癌中,SSRP1呈现高表达;高表达SSRP1的乳腺癌样本与患者年龄、p53突变及缺失、雌激素受体表达水平、孕激素受体表达水平及组织学分级显著相关(P0.05);SSRP1高表达的乳腺癌患者预后更差(P0.05);SSRP1高表达的乳腺癌样本富集了与DNA复制、有丝分裂、细胞周期和DNA损伤修复相关的基因集。结论:SSRP1是乳腺癌发生发展过程中的重要癌基因,能影响患者的预后,并可作为乳腺癌的诊疗靶点。
[Abstract]:Objective: to investigate the relationship between SSRP1 and clinicopathological features of breast cancer, to evaluate the significance of SSRP1 in evaluating the prognosis of breast cancer, and to predict how SSRP1 affects the progression of breast cancer. Methods: the data sets of coding gene expression profiles in NCBI gene expression assembler were collected. The expression profile of breast cancer samples and the corresponding clinical information were analyzed retrospectively (chi-square test) and prognosis analysis (Kaplan-Meier method), and GSEA method was used to analyze and predict the enriched gene sets in the high expression samples of SSRP1. Results: high expression of SSRP1 was found in breast cancer, and high expression of SSRP1 was associated with p53 mutation and deletion and estrogen receptor expression in patients with breast cancer. The expression level of progesterone receptor and histological grade were significantly correlated with the prognosis of breast cancer patients with high expression of P0.05 and SSRP1. The breast cancer samples with high expression of P0.05 and SSRP1 enriched the gene sets related to DNA replication, mitosis, cell cycle and DNA damage repair. Conclusion SSRP1 is an important oncogene in the development of breast cancer. It can affect the prognosis of breast cancer and can be used as a target for diagnosis and treatment of breast cancer.
【作者单位】：武汉大学人民医院神经外科;武汉大学人民医院消化内科;武汉大学第一临床学院;
【分类号】：R737.9

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