睾丸弥漫大B细胞淋巴瘤中MyD88及CD79B基因突变及意义

发布时间：2018-04-23 17:51

本文选题：睾丸肿瘤 + 淋巴瘤　；参考：《临床与实验病理学杂志》2017年12期

【摘要】：目的探讨睾丸原发性弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)中MyD88及CD79B基因突变及意义。方法回顾性分析15例睾丸原发性DLBCL的临床病理学特点,采用免疫组化及Sanger测序法检测原发性DLBCL中MyD88及CD79 B基因突变,分析MyD88及CD79B基因突变与肿瘤临床病理学特点、NF-κB蛋白在细胞核表达之间的关系。结果免疫组化显示15例DLBCL均为非生发中心B(non germinal center B,non-GCB)细胞型,4例存在CD79B基因Y196位点突变(26.7%),7例存在MyD88基因L265位点突变(46.7%),3例同时存在CD79B及MyD88基因突变(20%)。8例患者获得随访,未发现CD79B及MyD88基因突变与预后的相关性。结论中国人睾丸原发性DLBCL中存在较高的CD79B基因Y196位点和(或)MyD88基因L265位点突变,为针对这些突变基因的分子靶向治疗提供依据。
[Abstract]:Objective to investigate the mutation and significance of MyD88 and CD79B genes in primary diffuse large B cell lymphoma of testis (DLBCLs). Methods the clinicopathological features of 15 cases of primary testicular DLBCL were retrospectively analyzed. The mutations of MyD88 and CD79 B genes in primary DLBCL were detected by immunohistochemistry and Sanger sequencing. To analyze the relationship between MyD88 and CD79B gene mutation and the expression of NF- 魏 B protein in the nucleus. Results Immunohistochemistry showed that all 15 cases of DLBCL were non-germinal B(non germinal center Bnon-GCBC cell type. 4 cases had CD79B Y196 mutation and 7 cases had MyD88 L265 mutation 46.7T, 3 cases had CD79B and MyD88 gene mutation 20.8 cases were followed up. No correlation between CD79B and MyD88 gene mutation and prognosis was found. Conclusion there are high mutation of Y196 and / or L265 of CD79B gene in primary DLBCL of testis in Chinese, which provides the basis for molecular targeted therapy of these mutated genes.
【作者单位】：第四军医大学病理学教研室;第四军医大学西京医院病理科;
【基金】：国家自然科学基金(81472597)
【分类号】：R737.21

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