健康体检者与妇科门诊患者及宫颈癌患者人乳头瘤病毒基因型分布特点分析

发布时间：2018-04-23 16:33

本文选题：人乳头瘤病毒 + 基因型　；参考：《中华医院感染学杂志》2017年10期

【摘要】：目的探讨不同健康状态女性人乳头瘤病毒(HPV)的感染情况和亚型分布特点,为HPV感染诊治和宫颈癌预防提供重要依据。方法应用核酸分子快速导流杂交分型技术对遵义医学院附院2015年1-12月体检中心体检、妇科门诊就诊及肿瘤科确诊宫颈癌的女性患者22 419例进行HPV基因分型检测。结果宫颈癌确诊患者HPV感染率最高为84.42%,单一感染占83.50%,其次是妇科门诊就诊女性为37.47%,单一感染占80.36%,最后是体检女性为13.24%,单一感染占86.30%,三组间HPV感染率差异有统计学意义(P0.01);各组之间HPV亚型分布不同,均以高危亚型感染为主,其中健康体检者亚型感染频率最高的前3位是52、58、16亚型,分别占19.36%、11.28%、11.02%,门诊就诊女性亚型感染频率最高的前3位是52、16、58亚型,分别占17.92%、14.54%、10.97%,宫颈癌确诊患者亚型感染频率最高的前3位是16、52、18亚型,分别占33.88%、28.10%、19.00%。体检女性51岁以上HPV感染率较高(P0.01),门诊就诊女性HPV感染率最高的是61岁以上和15~20岁女性,分别为69.39%和53.61%(P0.01),而宫颈癌确诊者HPV感染率各年龄段差异不显著。结论 HPV感染普遍存在于不同健康状态的女性中,均以单一感染高危型为主,且与年龄有关,加强对各年龄段不同人群HPV筛查对宫颈癌的预防具有必要性。
[Abstract]:Objective to investigate the prevalence and subtype distribution of human papillomavirus (HPV) in women with different health status and to provide an important basis for the diagnosis and treatment of HPV infection and the prevention of cervical cancer. Methods HPV genotyping was performed in 22 419 female patients with cervical cancer diagnosed in gynecological outpatient clinic and oncology department by using nucleic acid molecular fast flow hybridization typing technique in the physical examination center of affiliated Hospital of Zunyi Medical College from January to December 2015. Results the highest HPV infection rate was 84.42 in patients with cervical cancer, 83.50 in single infection, 37.47 in female gynecological outpatients, 80.36 in single infection, and 13.24 in female physical examination and 86.30 in single infection. There was a statistical difference among the three groups in HPV infection rate. The distribution of HPV subtypes was different among the groups. The highest frequency of subtype infection was 52n5816 subtype, which accounted for 19.366.28% and 11.02%, respectively. The highest frequency of subtype infection in outpatient women was 52n16558 subtype. The highest frequency of subtype infection in patients with cervical cancer was 16.52%, accounting for 33.88% 28.10% and 19.00%, respectively. The infection rate of HPV was higher in females over 51 years of age than that in females over 51 years old. The infection rate of HPV was the highest in females over 61 years old and 15 ~ 20 years old, which was 69.39% and 53.61%, respectively. However, there was no significant difference in HPV infection rate among different age groups in patients with cervical cancer. Conclusion HPV infection is common in women with different health status, and it is mainly high risk type of single infection, which is related to age. It is necessary to strengthen HPV screening in different age groups for the prevention of cervical cancer.
【作者单位】：遵义医学院附属医院医学检验科;遵义医学院医学检验系;
【基金】：贵州省教育厅自然科学研究基金资助项目(黔教合KY字2012079) 贵州省科技厅联合基金资助项目(黔科合J字LKZ2011-35)
【分类号】：R737.33

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