汉族老年人高血压与瘦素受体基因rs1137100和rs1137101多态性的研究

发布时间：2018-04-26 07:26

本文选题：瘦素受体 + 单核苷酸多态性　；参考：《首都医科大学学报》2017年03期

【摘要】：目的探讨汉族老年人高血压与瘦素受体基因rs1137100和rs1137101多态性位点(single nucleotide polymorphism,SNP)之间的关系。方法采用Taqman方法检测267例汉族高血压老年人和255例健康老年人的瘦素受体基因rs1137100和rs1137101基因型及等位基因频率分布状况,测定所有研究对象的血脂、血糖、血浆瘦素和胰岛素,分析各SNP位点基因型与高血压的相关性。结果高血压组体质量指数(body mass index,BMI)、腰围(waist circumferences,WC)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)浓度均显著高于健康对照组,瘦素浓度显著低于健康对照组;rs1137100和rs1137101位点GG、GA和AA基因型以及A等位基因频率在2组间的分布相似;rs1137100位点GG、GA基因型的TC和LDL-C显著低于AA基因型;rs1137101位点GG、GA基因型的TC和LDL-C显著低于AA基因型,GA+AA组的TC和LDL-C显著高于GG组;Logistic回归分析结果表明,与GG型研究对象相比,rs1137100位点GA型、AA型研究对象发生高血压的风险相似,OR值分别为0.88(95%CI:0.59~1.28)和1.15(95%CI:0.78~1.70);在rs1137101位点上,与GG型研究对象相比,GA型、AA型研究对象发生高血压的风险相似,OR值分别为0.90(95%CI:0.59~1.38)和1.11(95%CI:0.72~1.71)。结论未发现瘦素受体基因rs1137100和rs1137101位点的变异与汉族老年人高血压有明显相关性。
[Abstract]:Objective to investigate the relationship between hypertension and leptin receptor gene rs1137100 and single nucleotide polymorphismNPs in the elderly of Han nationality. Methods the frequencies of rs1137100 and rs1137101 genotypes and alleles of leptin receptor gene were detected by Taqman method in 267 hypertensive elderly and 255 healthy controls. Blood lipid, blood glucose, plasma leptin and insulin were measured in all subjects. The relationship between genotype of SNP locus and hypertension was analyzed. Results body mass index (mass), body mass index (BMI), waist circumference (WCC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride-triglyceride (TGG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were significantly higher than those in healthy controls. The concentrations of leptin were significantly lower than those in the healthy control group (r / s 1137100 and rs1137101), the distribution of GA and AA genotypes and the frequencies of A alleles were similar between the two groups. The TC and LDL-C of GGG GA genotype at rs1137100 locus were significantly lower than those of the GGG GGGGG GG GG gene genotypes with AA genotype rs1137101. TC and LDL-C of GA AA group were significantly higher than those of GG group by logistic regression analysis. Compared with GG study subjects, the OR values of risk of hypertension were 0.88% 95% CI: 0.59% 1.28) and 1.15 95 CI: 0.78% 1.70% in GA / AA type subjects, respectively, at the rs1137101 locus. Compared with the GG study subjects, the OR values of the patients with GA / AA type were 0.90 / 95 CI: 0.59 / 1.38) and 1.1195 / 0.72 / 1.71 respectively. Conclusion there is no significant correlation between the variation of leptin receptor gene rs1137100 and rs1137101 loci and hypertension in the elderly of Han nationality.
【作者单位】：中国疾病预防控制中心营养与健康所微量元素营养室国家卫生和计划生育委员会微量元素重点实验室;
【基金】：国家自然科学基金(30671750)~~
【分类号】：R544.1

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