HPA基因多态性及其等位基因对血小板输注效果的影响

发布时间：2018-04-26 12:25

本文选题：HPA基因多态性 + 血小板　；参考：《中国输血杂志》2017年07期

【摘要】：目的探讨HPA基因多态性及其等位基因对血小板输注效果的影响。方法自2015年1月-2017年1月,连续性收集50例本院收治的血小板输注无效患者作为观察组,同期收集50例血小板输注有效的患者作为对照组,观察2组患者HPA基因多态性。结果与对照组比较,观察组患者供患双方HPA分型相合率显著降低(4.00%vs 82.00%,P0.05);血小板恢复百分比显著降低[(11.91±3.23)%vs(31.56±7.38)%,P0.05);血小板纠正增加指数显著降低(6.84±2.27 vs 16.38±1.92,P0.05)。2组患者HPA等位基因(HPA1-6,9,15)均以纯合子aa为多见。但观察组HPA-2等位基因为aa、ab、bb的分别有37、8、5例,对照组分别有48、2、0例,差异有统计学意义(P0.05);观察组HPA-3等位基因为aa、ab、bb的分别有33、9、8例,对照组分别有46、3、1例,差异有统计学差异(P0.05)。观察组HPA-15等位基因为aa、ab、bb的分别有35、8、7例,对照组分别有47、2、1例,差异有统计学意义(P0.05)。2组患者的血小板供者HPA等位基因(HPA1-6,9,15)均以纯合子aa为多见,差异均无统计学意义(P0.05)。血小板输注无效患者HPA-2,3等位基因为aa、ab和bb的血小板恢复百分比、血小板纠正增加指数逐步下降(P0.05)。结论血小板输注无效与HPA基因多态性有关,等位基因型b可能是导致血小板输注无效的原因。
[Abstract]:Objective to investigate the effect of HPA gene polymorphism and its allele on platelet transfusion. Methods from January 2015 to January 2017, 50 consecutive patients with ineffective platelet transfusion were collected as observation group and 50 patients with effective platelet transfusion as control group. The polymorphism of HPA gene was observed in both groups. Results compared with the control group, In the observation group, the consistent rate of HPA typing was significantly decreased by 4.00 vs 82.00, the percentage of platelet recovery was significantly decreased [11.91 卤3.23)%vs(31.56 卤7.38] and the platelet correction index was significantly decreased (6.84 卤2.27 vs 16.38 卤1.92 P0.05.2). However, the HPA-2 allele of the observation group was aaaababanbb (37 / 85) and the control group (48 / 22), the difference was statistically significant (P0.05), the HPA-3 allele of the observation group was aaaababambb (339 / 8) and the control group (466 / 31), respectively (P 0.05). In the observation group, the allele of HPA-15 was aaaababanbb in 37 cases and that in the control group was 47 cases. The difference between the two groups was statistically significant (P 0.05). The homozygote AA was the most common allele in the platelet donor group (P 0.05), and there was no significant difference in the difference between the two groups (P 0. 05%, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). The alleles of HPA-2M3 in patients with ineffective platelet transfusion were the percentage of platelet recovery of aaqinab and BB, and the increase index of platelet correction decreased gradually (P 0.05). Conclusion HPA gene polymorphism is associated with platelet transfusion failure, and allelic genotype b may be the cause of platelet transfusion failure.
【作者单位】：上海交通大学医学院附属第九人民医院输血科;
【基金】：上海市卫生计划委员会项目上海市第四轮公共卫生重点学科建设项目(15GWZK0501)
【分类号】：R457.1

【相似文献】