FCER2基因rs28364072位点多态性与哮喘的相关性

发布时间：2018-05-07 13:35

本文选题：哮喘 + FCER基因　；参考：《实用医学杂志》2017年03期

【摘要】：目的:探讨中国汉族人群FCER2基因rs28364072位点多态性与哮喘的相关性。方法:对120例中国汉族哮喘患者(哮喘组)及116名汉族健康者(对照组),应用聚合酶链(PCR)反应、DNA测序、哮喘控制测试(ACT)评分、肺功能测定等方法。结果:不同种族人群FCER2基因rs28364072位点基因型分布及等位基因频率的比较差异有统计学意义。在我国汉族哮喘及健康者中,均存在TT、TC和CC三种基因型。在哮喘组与对照组中,各基因型分布频率及等位基因频率比较差异均有统计学意义。相对TT基因型而言,CC基因型、CC+TC均能显著增加哮喘发生的危险性。相对T而言,突变C能显著增加哮喘发生的危险性。在哮喘组TT与CC基因型的ACT评分、血嗜酸性粒细胞百分比(EOS%)比较差异有统计学意义。结论:我国汉族人群存在着FCER2基因rs28364072位点多态性,且其多态性与哮喘患病相关。
[Abstract]:Objective: To explore the correlation between the polymorphism of FCER2 gene rs28364072 locus in Chinese Han population and asthma. Methods: 120 Chinese Han asthma patients (asthma group) and 116 Han healthy people (control group) were used to use polymerase chain reaction (PCR) reaction, DNA sequencing, asthma control test (ACT) score and lung function test. Results: FCE in different ethnic groups. There were significant differences in the genotype distribution and allele frequency of the R2 gene rs28364072 loci. There were three genotypes of TT, TC and CC among the Chinese Han asthma and healthy people. In the asthma group and the control group, the distribution frequency and the allele frequency difference were statistically significant. Relative TT genotypes, CC Genotype, CC+TC can significantly increase the risk of asthma. Compared with T, the mutation C can significantly increase the risk of asthma. In the asthma group, the ACT score of the TT and CC genotypes and the percentage of blood eosinophils (EOS%) are statistically significant. Conclusion: there is a rs28364072 polymorphism of FCER2 gene in Chinese Han population. And its polymorphism is associated with asthma.

【作者单位】：广东省深圳市宝安区人民医院;
【基金】：2016年深圳市宝安区科技局课题(编号:2016CX184)
【分类号】：R562.25

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