新疆不同民族IL-6和IL-10基因多态性

发布时间：2018-05-10 13:39

  本文选题：白细胞介素- + 白细胞介素-　； 参考：《广东医学》2017年14期

【摘要】：目的研究中国新疆地区维、汉、哈3个民族白细胞介素-6(IL-6)和白细胞介素-10(IL-10)基因多态性。方法采用SNa Pshot SNP分型技术检测中国新疆地区健康人群(维吾尔族231人、汉族204人、哈萨克族80人)外周血标本中IL-6和IL-10基因共6个位点单核苷酸多态性(SNP),并进行民族间比较。结果在6个候选SNP位点中,汉族与维吾尔族和哈萨克族在所有位点(rs1800795、rs1800797、rs1800890、rs1800896、rs1800871和rs1800872)等位基因和基因型频率分布差异有统计学意义(P0.05),维吾尔族与哈萨克族在2个位点(rs1800795和rs1800797)等位基因和基因型频率分布差异有统计学意义(P0.05)。结论 IL-6和IL-10基因多态性在新疆不同民族间分布存在显著差异。
[Abstract]:Objective to study the polymorphism of interleukin -6 (IL-6) and interleukin -10 (IL-10) gene of 3 ethnic groups in Xinjiang, China. Methods the SNa Pshot SNP typing was used to detect the 6 loci of IL-6 and IL-10 in the peripheral blood samples of the healthy population of Xinjiang, China (231 Uygur, 204 Han, Kazak). Glucoside polymorphism (SNP) and inter ethnic comparison. Results in the 6 candidate SNP loci, the allele and genotype frequency distribution of the Han and Uygur and Kazakh alleles (rs1800795, rs1800797, rs1800890, rs1800896, rs1800871 and rs1800872) were statistically significant (P0.05), and the Uygur and Kazakh people were in 2 sites. There was significant difference in the allele and genotype frequency distribution of the points (rs1800795 and rs1800797) (P0.05). Conclusion the distribution of IL-6 and IL-10 gene polymorphisms was significantly different among different ethnic groups in Xinjiang.

【作者单位】： 广州医科大学附属第四医院病理科;广州医科大学附属第一医院病理科;新疆维吾尔自治区人民医院血液科;兰州军区乌鲁木齐总医院临床医学研究所;新疆医科大学第二附属医院血液科;
【基金】：国家自然科学基金资助项目(编号:30860096)
【分类号】：R394
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本文编号：1869526