乌鲁木齐地区维、汉族儿童哮喘与ADAM33基因多态性的相关性

发布时间：2018-05-11 16:58

本文选题：ADAM基因 + 位点多态性　；参考：《临床儿科杂志》2016年12期

【摘要】：目的探讨乌鲁木齐地区维、汉族儿童支气管哮喘与ADAM33基因多态性的相关性。方法选取同期3~15岁于乌鲁木齐地区生活的86例维族和111例汉族哮喘患儿,同时纳入64例汉族、56例维族健康儿童为对照组;采用聚合酶链反应对ADAM33基因V4、T2位点进行单核苷酸多态性(SNP)分型,并对其中部分进行基因检测验证。结果哮喘组和对照组之间,ADAM33基因V4、T2位点三种基因型的分布差异有统计学意义(P均0.01);V4位点哮喘组CC基因型频率较高,与G等位基因个体比较,C等位基因携带者儿童发生哮喘的风险增加1.51倍(95%CI:1.10~2.09);T 2位点哮喘组AA基因型频率较高,与G等位基因个体比较,A等位基因携带者儿童发生哮喘的风险增加1.96倍(95%CI:1.32~2.91)。汉族儿童中,哮喘组和对照组之间ADAM 33基因V 4、T 2位点三种基因型分布的差异无统计学意义(P均0.05);而维族儿童中,V 4、T 2位点三种基因型分布的差异有统计学意义(P均0.05)。结论 ADAM 33基因V 4、T 2位点与乌鲁木齐地区维族儿童哮喘发病相关。
[Abstract]:Objective to investigate the association between bronchial asthma and ADAM33 gene polymorphism in Uygur and Han children in Urumqi. Methods 86 Uygur and 111 Han asthmatic children aged from 3 to 15 years old in Urumqi were selected and 64 healthy children of Han nationality were included as control group. Single nucleotide polymorphisms (SNPs) of ADAM33 gene V4T 2 were detected by polymerase chain reaction (PCR), and some of them were detected and verified. Results the frequency of CC genotype was higher in asthmatic group than that in control group. There were significant differences among the three genotypes at V4 / T2 locus of ADAM33 gene in asthmatic group (P = 0.01) and control group (P < 0.05), and the frequency of CC genotype was higher in asthmatic group than in control group. Compared with individuals with G allele, the risk of asthma in children with C allele was increased by 1.51 times and 95 times than that in asthmatic children with T _ 2 locus at CI _ 1: 1.10 ~ 2.09. The frequency of AA genotype was higher in asthmatic children with C allele. Compared with individuals with G allele, the risk of asthma in children with allele A was 1.96 times higher than that in individuals with G allele. In Han children, there was no significant difference in the distribution of the three genotypes of ADAM 33 gene V4T2 locus between asthma group and control group (P 0.05), but there was significant difference among Uygur children (P 0.05). Conclusion V _ 4 T _ 2 of ADAM 33 gene is associated with asthma in Uygur children in Urumqi.
【作者单位】：新疆医科大学第五附属医院儿科;新疆医科大学第一附属医院儿科;
【基金】：新疆维吾尔族自治区自然科学基金(No.2014211C130)
【分类号】：R725.6

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