色氨酸羟化酶基因与青年人自杀未遂的关联研究

发布时间：2018-05-18 04:27

本文选题：色氨酸羟化酶基因 + 色氨酸羟化酶基因　；参考：《重庆医科大学学报》2017年05期

【摘要】：目的:探讨色氨酸羟化酶1(tryptophan hyroxylase 1,TPH1)基因多态性和色氨酸羟化酶2(tryptophan hyroxylase 2,TPH2)基因多态性与青年人自杀未遂行为的关系。方法:采用i MLDRTM多重SNP分型技术对102例青年自杀未遂者(自杀未遂组)和112名青年健康对照(对照组)TPH1基因多态性位点rs1800532、rs211105、rs4537731、rs684302、rs7933505和TPH2基因多态性位点rs10748185、rs11178997、rs1386493、rs1843809、rs4448731、rs7305115、rs9325202进行基因分型,并对基因型、等位基因、单体型频率进行比较。结果:(1)单位点分析显示:以上12个多态性位点基因型及等位基因频率分布在自杀未遂组与对照组之间差异无统计学意义(P0.05);(2)单体型分析显示:由TPH1基因5个位点组成的单体型G-G-C-C-G、G-G-T-T-G、G-TC-C-G、G-T-T-C-G、T-T-T-T-A频率在自杀未遂组和对照组间差异无统计学意义(P0.05);由TPH2基因7个位点组成的单体型G-T-G-T-T-A-G频率在自杀未遂组和对照组间差异有统计学意义(χ2=10.034,P=0.002),经Bonferroni校正检验后,差异仍有统计学意义(P=0.024)。结论:TPH2基因7个SNP位点构成的单体型G-T-G-T-T-A-G可能与增加青年人的自杀未遂相关。
[Abstract]:Objective: To investigate the relationship between the polymorphism of tryptophan hydroxylase 1 (tryptophan hyroxylase 1, TPH1) gene and the polymorphism of tryptophan hydroxylase 2 (tryptophan hyroxylase 2, TPH2) and suicide attempt in young people. Methods: 102 cases of suicide attempted suicide (suicide attempted group) and 112 young people were treated by I MLDRTM multiple SNP typing. TPH1 gene polymorphic loci rs1800532, rs211105, rs4537731, rs684302, rs7933505 and TPH2 polymorphic loci rs10748185, rs11178997, rs1386493, rs1843809, rs4448731, and alleles were genotyping, and the genotype, allele, and haplotype frequency were compared. Results: (1) unit point analysis showed that: above There was no significant difference in the frequency distribution between the 12 polymorphic loci and the allele frequencies between the attempted suicide group and the control group (P0.05). (2) the haplotype analysis showed that the frequency of the haplotype G-G-C-C-G, G-G-T-T-G, G-TC-C-G, G-T-T-C-G, and T-T-T-T-A of the 5 loci of the TPH1 gene was not statistically significant between the attempted suicide group and the control group. P0.05; the frequency of haplotype G-T-G-T-T-A-G composed of 7 TPH2 loci was statistically significant between the attempted suicide group and the control group (x 2=10.034, P=0.002). The difference was still statistically significant (P=0.024) after Bonferroni correction test (P=0.024). Conclusion: the haplotype G-T-G-T-T-A-G of the 7 SNP loci of TPH2 gene may be associated with the increase of youth. The attempted suicide of a person is related.
【作者单位】：重庆医科大学附属大学城医院心理卫生中心;重庆医科大学附属第一医院心理卫生中心;
【基金】：国家自然科学基金资助项目(编号:81071118) 重庆市卫计委医学科研面上资助项目(编号:2015MSXM065);重庆市卫计委医学科研重点资助项目(编号:2015ZDXM006) 重庆市社会事业与民生保障科技创新专项资助项目(编号:cstc2015shms-ztzx10011)
【分类号】：B846;R749.99

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