LEPR基因多态性与未绝经女性BMI变化的关系研究

发布时间：2018-05-21 10:44

  本文选题：瘦素受体基因多态性 + 未绝经女性　； 参考：《现代预防医学》2017年09期

【摘要】：目的探讨瘦素受体(LEPR)基因多态性与未绝经女性近5年体质指数(BMI,)变化之间的关系。方法采用横断面研究,于2015年3月~6月收集四川省人民医院体检中心和成都双流区妇保院体检中心未绝经健康女性463人,收集其一般人口学特征、人口测量指标、日均能量摄入等信息,以5年前BMI与现在的BMI变化情况将研究对象分为低风险组(BMI5year24 kg/m~2→BMI_(present)24 kg/m~2BMI_5year≥24 kg/m~2→BMI_(present)24 kg/m~2)、增重至超重组(BMI_5year24kg/m~2→BMI_(present)≥24kg/m)、持续超重/肥胖组(BMI_5year≥24 kg/m2→BMI_(present)≥24kg/m~2)。采用飞行时间质谱检测LEPRrs1137100,LEPRrs1137101基因型。采用多分类Logistic回归,估计LEPR基因多态性与未绝经健康女性人群近5年BMI变化的关联值(OR)。结果 LEPR rs1137100和LEPR rs1137101突变等位基因的携带率分别为83.3%和89.0%;调整重要的混杂因素后,携带LEPRrs1137100AA+AG或LEPRrs1137101AA+AG可增加发生持续超重/肥胖的风险(OR=1.67,95%CI:1.02-2.73;OR=1.76,95%CI:1.01-3.07)。结论LEPRrs1137100和LEPRrs1137101基因多态性可能与未绝经女性持续超重/肥胖有关。
[Abstract]:Objective to investigate the relationship between leptin receptor (Lepr) gene polymorphism and body mass index (BMI) in unmenopausal women in recent 5 years. Methods A cross-sectional study was conducted to collect 463 unmenopausal healthy women from the physical examination Center of Sichuan Provincial people's Hospital and the Medical examination Center of Shuangliu District in Chengdu from March to June 2015. The general demographic characteristics and population measurement indexes were collected. According to the changes of BMI and current BMI 5 years ago, the subjects were divided into low risk group (BMI5year24 kg/m~2 / BMI_(present)24 kg/m~2BMI_5year 鈮，

本文编号：1918878