肠道病毒71型感染手足口病S100B基因多态性研究

发布时间：2018-05-21 21:02

本文选题：肠道病毒型 + 手足口病　；参考：《中国当代儿科杂志》2017年08期

【摘要】：目的研究S100B基因rs9722位点基因多态性与肠道病毒71型(EV71)感染手足口病(HFMD)的相关性。方法以124例EV71感染HFMD患儿为研究对象,56例健康儿童作为对照组,两组均进行S100B基因rs9722位点基因多态性检测;并且74例HFMD患儿进行血清S100B蛋白检测。结果 S100B基因rs9722位点检出3种基因型:CC型、CT型和TT型,基因型频率分布符合Hardy-Weinberg平衡。与对照组比较,HFMD组患儿S100B基因rs9722位点TT基因型频率和T等位基因频率明显增高(P0.01)。重症EV71感染相关HFMD患儿TT基因型频率和T等位基因频率均明显高于普通型患儿(P0.05)。与痊愈组比较,HFMD不良预后组的S100B基因rs9722位点TT基因型频率和T等位基因频率明显增高(P0.05)。74例HFMD患儿各基因型的血清S100B蛋白水平以TT基因型最高,CC型最低(P0.01)。结论 S100B基因rs9722位点T等位基因可能是EV71感染HFMD发展为重症的危险因素。
[Abstract]:Objective to study the association between S100B gene rs9722 locus polymorphism and enterovirus 71 (EV71) infection with HFMD (hand, foot and mouth disease). Methods the S100B gene rs9722 locus polymorphism and serum S100B protein were detected in 124 cases of HFMD infected with EV71 and 56 healthy children as control group. Results three genotypes (CT and TT) were detected at the rs9722 locus of S100B gene. The genotype frequency distribution was in line with the Hardy-Weinberg equilibrium. Compared with the control group, the frequency of TT genotype and T allele at rs9722 site of S100B gene were significantly increased in children with S100B gene. The frequency of TT genotype and T allele in HFMD patients with severe EV71 infection was significantly higher than that in normal children (P 0.05). Compared with the cured group, the frequency of TT genotype and T allele at the rs9722 site of S100B gene was significantly higher than that in the cured group. The serum S100B protein level of each genotype in 74 patients with HFMD was the highest in TT genotype and the lowest in CC genotype. Conclusion T allele at rs9722 site of S100B gene may be a risk factor for the development of EV71 infection with HFMD.
【作者单位】：青岛大学附属青岛市妇女儿童医院重症医学中心PICU;
【分类号】：R725.1

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