辣椒抽提物对缓解小鼠食源性肥胖及调控基因表达的作用

发布时间：2018-05-24 09:01

本文选题：辣椒 + 减肥　；参考：《现代食品科技》2017年05期

【摘要】：本文比较了二荆条辣椒乙醇抽提物与纯化的辣椒碱对食源性小鼠肥胖的影响,为辣椒抽提物减肥提供理论依据。C57BL/6小鼠被分为四组,分别为对照组、肥胖组(喂食高脂饲料)、辣椒醇提物组(辣椒抽提物+高脂饲料),辣椒碱组(纯化的辣椒碱+高脂饲料)。结果表明,与纯化的辣椒碱相比,辣椒提取物更加有效地抑制体重增加,减少脂肪积累、减小脂肪细胞大小,降低血清、肝脏和粪便甘油三酯(TG)和总胆固醇(TC)的含量。在肝脏和脂肪组织中,脂分解基因(PPARα、CYP7A1、LPL和CPT1α)在肥胖组显著下降,但在辣椒醇提物组和辣椒碱组的显著上调,并且辣椒醇提物组上调程度更高;促脂合成基因PPARγ和C/EBPα在肥胖组、辣椒醇提物组和辣椒碱组都上调,但辣椒醇提物组的上调程度最小。因此,辣椒提取物和辣椒碱都能起到减肥作用,但是辣椒提取物效果更好。
[Abstract]:In this paper, the effects of ethanol extract and purified capsaicin on obesity in edible mice were compared, and the theoretical basis for weight loss of capsicum extract. C57BL / 6 mice were divided into four groups, respectively, as control group. Obesity group (fed with high fat diet, capsaicin alcohol extract group (capsicum extract, high fat feed), capsaicin group (purified capsaicin high fat feed). The results showed that compared with purified capsaicin, capsicum extract was more effective in inhibiting weight gain, reducing fat accumulation, reducing fat cell size, reducing serum, liver and fecal triglyceride (TG) and total cholesterol (TC) contents. In liver and adipose tissue, the lipolytic gene PPAR- 伪 (CYP7A1) LPL and CPT1 伪 decreased significantly in obese group, but increased significantly in capsaicin group and capsaicin group, and increased in capsaicin group, and PPAR 纬 and C/EBP 伪 genes were up-regulated in obese group. Capsaicin group and capsaicin group were up-regulated, but capsaicin group was the least. Therefore, capsicum extract and capsaicin can play a role in weight loss, but the effect of pepper extract is better.
【作者单位】：湖北工业大学生物工程与食品学院工业发酵湖北省协同创新中心湖北省食品发酵工程技术研究中心;
【基金】：湖北省大学生创新创业训练计划项目(201410500019) 湖北省自然科学基金项目(2015CFB678) 湖北省教育厅科学技术研究计划青年人才项目(Q20151412) 湖北工业大学博士启动基金项目(BSQD10036)
【分类号】：TS201.4

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