ADAM33基因多态性与中国汉族人群支气管哮喘相关性的Meta分析

发布时间：2018-05-25 05:44

本文选题：支气管哮喘 + 解整合素-金属蛋白酶　；参考：《中国循证医学杂志》2016年01期

【摘要】：目的系统评价解整合素-金属蛋白酶33(ADAM33)基因T2(rs2280090)、S2(rs528557)和V4(rs2787094)位点多态性与中国汉族人群支气管哮喘的相关性。方法计算机检索Pub Med、Web of Science、CNKI、Wan Fang Data和VIP数据库,搜集有关ADAM33基因多态性与中国汉族人群支气管哮喘相关性的病例-对照研究,检索时限均为建库至2014年12月。由两位研究者独立筛选文献、提取资料,并评价纳入研究的偏倚风险后,采用Stata 12.1软件进行Meta分析。结果最终纳入8个病例-对照研究,包括1 651例支气管哮喘患者和1 639例对照。Meta分析结果显示:在总体研究中,ADAM33基因T2多态性与哮喘发病风险降低具有相关性[AA+AG vs.GG:OR=0.316,95%CI(0.151,0.659),P=0.002],S2多态性与哮喘发病风险增加具有相关性[GG+GC vs.CC:OR=1.271,95%CI(1.023,1.578),P=0.030],但V4多态性与哮喘发病风险不具有相关性[GG+GC vs.CC:OR=1.561,95%CI(0.638,3.823),P=0.330]。按照年龄进行的亚组分析结果提示,T2多态性与降低成人和儿童哮喘发病风险均有相关性,S2多态性与增加成人哮喘发病风险具有相关性,但V4多态性与成人和儿童哮喘发病风险均无相关性。结论ADAM33基因T2和S2多态性与中国汉族人群支气管哮喘发病风险具有相关性。受纳入研究的数量和质量的限制,上述结论尚需要更多研究予以证实。
[Abstract]:Objective to systematically evaluate the association between the polymorphism of integrin-metalloproteinase-33 (ADAM33) gene and bronchial asthma in Chinese Han population. Methods the Pub MedVIP Fang Data and VIP databases were searched by computer, and a case-control study on the association between ADAM33 gene polymorphism and bronchial asthma was conducted in Chinese Han population. The search time was established until December 2014. The two researchers independently sifted the literature, extracted the data and evaluated the bias risk in the study. The Meta analysis was carried out with Stata 12.1 software. Results finally included in 8 case-control studies, A meta-analysis of 1 651 patients with bronchial asthma and 1 639 controls showed that the T2 polymorphism of the ADAM33 gene was associated with a reduced risk of asthma in the overall study [AA AG vs.G: G: Orr 0.31695CI0.151 0. 59 P0. 002] the S2 polymorphism was associated with an increased risk of asthma. There was no correlation between V4 polymorphism and asthma risk [GG GC vs.CCG: OR1.271 ~ 95CII 1.023 ~ 1.578P0. 030], but there was no correlation between V4 polymorphism and asthma risk [GG GC vs.CC: OR1.561 ~ 95CII 0.6383.823 P0.330]. The results of age subgroup analysis showed that the T 2 polymorphism was associated with the reduction of asthma risk in both adults and children and increased the risk of asthma in adults. However, there was no correlation between V 4 polymorphism and asthma risk in adults and children. Conclusion the polymorphism of T 2 and S 2 of ADAM33 gene is associated with the risk of bronchial asthma in Chinese Han population. These findings need to be confirmed by more studies, limited by the quantity and quality of the studies included.
【作者单位】：新疆医科大学第一附属医院呼吸一科;
【基金】：国家自然科学基金(编号:81160004;8100026)
【分类号】：R562.25

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