中国地区汉族人类血小板抗原基因多态性研究

发布时间：2018-06-02 20:12

本文选题：人类血小板抗原 + 基因多态性　；参考：《基因组学与应用生物学》2017年02期

【摘要】：为探讨中国汉族人群的人类血小板特异性抗原(human platelet antigens,HPA)的基因多态性特点并对南北方汉族人群进行比较,本研究合并了24个地区的28篇HPA基因多态性调查文献中HPA-1、HPA-2、HPA-3、HPA-4、HPA-5、HPA-6和HPA-15的基因分型数据,利用统计学方法及相关软件进行整理,并对整理后数据进行对比分析。结果显示HPA-1、HPA-2、HPA-3、HPA-4、HPA-5和HPA-6位点的a、b基因频率差距很大且bb基因型频率接近于0,而HPA-3和HPA-15位点的a、b基因频率差距不大。南北方汉族人群的比较中,HPA-1和HPA-5的基因分型有所差异,而HPA-2的基因型频数分布差异有统计学意义(p0.05)。此结果旨在获取人类血小板抗原基因多态性的特点并提供建立人类血小板抗原数据库的相关资料,对临床输血的指导具有重要意义。
[Abstract]:To investigate the genetic polymorphism of human platelet specific antigen (platelet antigensus) in Chinese Han population, and to compare the genetic polymorphism of human platelet specific antigen (platelet antigensus) in Han population in the south and the north. In this study, the genotyping data of HPA-1, HPA-2, HPA-3, HPA-4, HPA-5, HPA-5, HPA-6 and HPA-15 were collected from 28 papers of HPA gene polymorphism survey in 24 regions, and the data were compared and analyzed by statistical method and related software. The results showed that the frequency difference between HPA-2 and HPA-4 HPA-4 HPA-5 and HPA-6 locus was very large and the frequency of BB genotype was close to zero, but the frequency difference between HPA-3 and HPA-15 locus was not significant. The genotypes of HPA-1 and HPA-5 were different in the Han population of north and south, while the frequency distribution of HPA-2 genotype was significantly different (p0.05). The aim of this study is to obtain the characteristics of human platelet antigen gene polymorphism and to provide relevant data for establishing human platelet antigen database, which is of great significance to the guidance of clinical blood transfusion.
【作者单位】：广西医科大学;南宁急救医疗中心;广西医科大学生物化学与分子生物学教研室广西高校生物分子医学研究重点实验室;
【基金】：国家自然科学基金(81160263)资助
【分类号】：R440

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