跳远运动员α辅肌动蛋白-3基因多态性研究

发布时间：2018-06-07 04:25

本文选题：α辅肌动蛋白- + 基因多态　；参考：《现代预防医学》2017年04期

【摘要】：目的研究α辅肌动蛋白-3(ACTN-3)基因C1747T多态在汉族跳远运动员中的分布特点。方法无创口腔拭子基因组DNA提取试剂盒提取111名跳远运动员和213名普通人全基因组DNA,并利用PCR-RFLP检测ACTN-3基因C1747T多态性,Hardy-Weinberg遗传平衡定律、SPSS对比分析跳远运动员与普通人群、不同专项运动员之间ACTN-3基因多态分布差异。结果跳远运动员和普通人群ACTN-3基因C1747T多态分布符合遗传平衡;跳远运动员ACTN-3基因CC型和C等位基因明显高于普通人群(χ2=7.407,P=0.006;χ2=6.344,P=0.012);不同性别跳远运动员之间ACTN-3基因多态分布差异无统计学意义(χ2=0.279,P=0.870);跳远运动员ACTN-3基因C1747T多态分布与长跑运动员相比,差异有统计学意义(χ2=6.755,P=0.034);而与举重、排球运动员比较,差异无统计学意义(χ2=0.173,P=0.917;χ2=3.088,P=0.213)。结论 ACTN-3基因CC型与速度力量素质相关,可作为跳远运动员选拔和培养的分子标记;不同专项运动员之间ACTN-3基因C1747T多态分布特点不同。
[Abstract]:Objective to study the distribution of C1747T polymorphism of 伪 -coactin -3ACTN-3 gene in Han Chinese long jump athletes. Methods the genomic DNA extraction kit of non-invasive oral swabs was used to extract the genomic DNA of 111 long jumpers and 213 ordinary people. The ACTN-3 gene C1747T polymorphism and Hardy-Weinberg genetic balance law were detected by PCR-RFLP. The polymorphic distribution of ACTN-3 gene was different among different athletes. Results the distribution of C1747T polymorphism of ACTN-3 gene in the long jump athletes and the general population was in accordance with the genetic balance. The CC and C alleles of ACTN-3 gene in long jumpers were significantly higher than those in the general population (蠂 27.407 P0. 006; 蠂 2 6.344; P < 0. 012); there was no significant difference in the distribution of ACTN-3 gene polymorphism among different genders (蠂 2 + 0. 279); the ACTN-3 gene C1747T polymorphism distribution of long jump athletes was significantly higher than that of long distance runners. The difference was statistically significant (蠂 ~ 2 = 6.755P ~ (0.034), but there was no significant difference between the two groups (蠂 ~ 2 = 0.173, P ~ (0.917); 蠂 ~ 2 = 3.088P ~ (0.213). Conclusion the CC type of ACTN-3 gene is related to the quality of speed and strength and can be used as a molecular marker for selection and cultivation of long jumpers, and the distribution characteristics of C1747T polymorphism of ACTN-3 gene are different among different special athletes.
【作者单位】：四川工商学院体育部;四川省肿瘤医院;
【基金】：四川工商学院2016年课题
【分类号】：R87;G823.3

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