中国西北部地区汉族患者麻醉药物相关基因多态性的分布

发布时间：2018-06-07 17:30

本文选题：基因多态性 + 西北地区　；参考：《临床麻醉学杂志》2017年12期

【摘要】：目的对中国西北部地区汉族手术患者OPRM1、CYP3A4*1G、SLCO1B1和ABCB1的基因型种类进行回顾,明确与镇痛和肌松相关的基因突变率。方法西京医院2016年9月至2017年4月籍贯为西北地区省市(陕西、甘肃、宁夏、青海、新疆)的汉族手术患者3 213例,男1 492例,女1 721例,对其OPRM1、CYP3A4*1G、SLCO1B1和ABCB1基因多态性检测结果进行回顾。结果 OPRM1(118AG)突变杂合子AG型的占比为42.11%,突变纯合子GG型的占比为12.14%。CYP3A4*1G的CC、TT、TC、CT的占比分别为29.69%、4.17%、65.67%、0.47%。SLCO1B1杂合子AG型的占比为37.44%,GG型的占比为55.21%。ABCB1的CC、TT、TC、CT的占比分别为13.07%、44.60%、0.28%、42.05%。男性和女性各基因型分布差异无统计学意义。结论西北汉族手术患者中与芬太尼等阿片类药物和罗库溴铵用量相关的4个基因位点突变率均较高,提示基因多态性序列测定指导麻醉用药具有重要临床价值。
[Abstract]:Objective to review the genotypes of OPRM1CY CYP3A4A4G, SLCO1B1 and ABCB1 in patients undergoing surgery in northwestern China, and to identify the gene mutation rates related to analgesia and muscle relaxation. Methods from September 2016 to April 2017, there were 3,213 patients (1,492 males and 1,721 females) of Han nationality in Northwest China (Shaanxi, Gansu, Ningxia, Qinghai, Xinjiang) in Xijing Hospital. The results of polymorphism detection of CYP3A4GG, SLCO1B1 and ABCB1 genes in OPRM1 were reviewed. Results the proportions of AG type and GG type of homozygote were 42.11 and 12.14.CYP3A41G, respectively. The percentage of CCTTTTCNCT was 29.699.690.670.47.SLCO1B1 heterozygous AG was 55.21.ABCB1 CCTTCCT was 13.070.600.280.05. There was no significant difference in genotype distribution between male and female. Conclusion the mutation rates of four gene loci related to the dosage of fentanyl and rocuronium in the surgical patients of the Northwest Han nationality were higher, suggesting that the sequencing of gene polymorphisms is of great clinical value in guiding anesthetic drugs.
【作者单位】：西京医院麻醉科;
【基金】：第四军医大学军事医学提升计划(No.2016TSB-014)
【分类号】：R614

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