血管紧张素转换酶基因多态性和脑小血管病相关性Meta分析

发布时间：2018-06-07 20:00

  本文选题：血管紧张素转换酶基因多态性 + 脑小血管病　； 参考：《华北理工大学》2016年硕士论文

【摘要】：目的对世界范围内血管紧张素转换酶基因多态性(ACE I/D)与脑小血管病相关性的研究进行Meta分析,明确ACE I/D基因多态性与脑小血管病发病是否相关。方法全面检索有关的血管紧张素转换酶基因多态性和脑小血管病相关性的文献,制定统一的检索策略,检索数据库包括中国知网、中国生物医学文献光盘数据库、医知网、万方、维普数据库,Pubmed、Google以及参考文献检索等手段。将检索到的文献按纳入排除标准进行筛选,再依据制定的质量评价表,对筛选出符合本研究要求的文献进行质量评价。统计学分析采用Cochrane协作网提供的Rev Man5.3软件,对二分类变量使用Mantel-Haenszel法进行合并分析,检验水准为α=0.05;用Q值和I2检查各独立研究的异质性,异质性检验水准设为α=0.1;潜在的发表偏倚用漏斗图评估。结果依据制定的统一检索策略,共检索出相关文献377篇,再依据制定的纳入标准和排除标准,最终纳入符合条件的独立研究共26篇,总共7094例受试对象。经过质量评价,11篇文献为高质量研究,15篇文献为中等质量研究。经分析结果显示:血管紧张素转换酶ACE(I/D)基因多态性与脑小血管病在显性模型下(DD+IDvs I I):OR=1.30,95%CI=(1.11,1.52),P=0.001;隐性模型(DDvs ID+II):OR=1.44,95%CI=(1.19,1.75),P=0.0002;共显性模型(DDvs II):OR=1.59,95%CI=(1.26,1.99),P0.0001以及(I Dvs II):OR=1.16,95%CI=(1.02,1.32),P=0.02;等位基因比较(Dvs I):OR=1.30,95%CI=(1.15,1.48),P0.0001。再分别对脑小血管病的不同临床分型和不同种族进行分析,多数遗传模型下可得到类似结果。结论通过上述研究结果说明血管紧张素转换酶(ACE I/D)基因多态性与脑小血管病的发病相关,DD基因型和D等位基因可以增加该疾病的患病风险。在亚洲人和高加索人中ACE I/D基因多态性与脑小血管病发生显著相关,该基因多态性与腔隙性脑梗死发生显著相关。
[Abstract]:Objective to investigate the association of ACE I / D polymorphism with cerebral microangiopathy in the world, and to determine whether ACE I / D polymorphism is related to the pathogenesis of cerebral microangiopathy. Methods A comprehensive search was carried out on the relationship between angiotensin converting enzyme gene polymorphism and cerebral microangiopathy, and a unified search strategy was established. The retrieval databases included China knowledge Network, Chinese Biomedical Literature CD-ROM database and Medical knowledge Network. Wanfang, Wiper Database, PubmedCon Google and reference search and other means. The retrieved documents were screened according to the exclusion criteria, and then the quality evaluation of the selected documents according to the quality evaluation table was carried out. The statistical analysis was performed with the software Rev Man5.3 provided by Cochrane Cooperative Network, and the Mantel-Haenszel method was used to combine the two classified variables. The test level was 伪 -0.05.The heterogeneity of each independent study was examined by Q and I2. The heterogeneity test level was set at 伪 -0. 1. The potential publication bias was evaluated by funnel graph. Results according to the unified retrieval strategy, a total of 377 articles were retrieved, and 26 independent studies were included according to the inclusion criteria and exclusion criteria. A total of 7094 subjects were included in the study. After quality evaluation, 11 articles were of high quality and 15 articles were of medium quality. 缁忓垎鏋愮粨鏋滄樉绀，

本文编号：1992624