上海市老年高血压患者中医证型与IL-10启动子rs1800871基因多态性的相关性分析

发布时间：2018-06-09 14:07

本文选题：老年高血压病 + 中医证型　；参考：《中华中医药学刊》2017年03期

【摘要】：目的:分析上海市老年高血压病中医证型与炎症因子IL-10启动子区rs1800871基因多态性的相关性,探索老年高血压病中医证型发病的基因遗传变异。方法:收取900例体检老年高血压患者,利用Nano Drop技术进行基因分型,分析高血压中医证型与IL-10 rs1800871基因多态性的关系。结果:IL-10 rs1800871基因多态性符合Hardy-Weinberg遗传平衡法则。高血压各中医证型TT、TC、CC分布无显著性差异(P0.05),经性别分层后,老年男性高血压患者高血压各中医证型中的分布具有显著差异,对老年男性高血压患者虚实证型变化具有显著影响。老年女性高血压患者高血压各中医证型中的分布不具有显著差异,虚实证型变化没有显著影响。结论:rs1800871基因多态性与老年男性高血压中医证型相关,与老年男性高血压虚实辨证相关。
[Abstract]:Objective: to analyze the relationship between TCM syndrome type of senile hypertension in Shanghai and rs1800871 gene polymorphism in the promoter region of inflammatory factor IL-10, and to explore the genetic variation of TCM syndrome type of senile hypertension. Methods: 900 elderly hypertensive patients were collected and genotyped by Nano drop technique. The relationship between TCM syndrome type of hypertension and IL-10 rs1800871 gene polymorphism was analyzed. Results the 1: IL-10 rs1800871 gene polymorphism was consistent with Hardy-Weinberg genetic balance rule. There was no significant difference in the distribution of TCU CC among TCM syndromes of hypertension. After sex stratification, the distribution of TCM syndromes of hypertension in elderly male patients was significantly different, which had a significant effect on the changes of deficiency and excess syndrome types in elderly male hypertensive patients. There was no significant difference in the distribution of TCM syndromes of hypertension in elderly women with hypertension, but there was no significant difference in the changes of deficiency and deficiency syndrome types. Conclusion the polymorphism of the 1: rs1800871 gene is related to the TCM syndrome type of hypertension in aged men, and to the differentiation of deficiency and deficiency of hypertension in elderly men.
【作者单位】：上海中医药大学附属龙华医院;上海人类基因组研究中心;
【基金】：国家中医药行业科研专项基金项目(201007003-4) 国家中医临床研究基地业务建设科研专项项目(JDZX2012114) 上海市卫生局科研项目(2010233)
【分类号】：R259

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