替比夫定对乙型肝炎E抗原阳性慢性乙肝孕妇血清辅助性T细胞和乙肝病毒基因载量的影响

发布时间：2018-06-12 04:33

本文选题：慢性乙型肝炎 + 替比夫定　；参考：《中华医院感染学杂志》2017年08期

【摘要】：目的观察替比夫定治疗前后乙型肝炎E抗原(HBeAg)阳性慢性乙型肝炎(CHB)患者血清辅助性T细胞(Th)和乙肝病毒基因(HBV DNA)载量的变化,分析替比夫定对于CHB母婴传播的影响。方法选取2013年8月-2015年7月医院接受替比夫定治疗的HBeAg阳性CHB孕妇92例为观察组,将仅接受保肝治疗的HBeAg阳性CHB孕妇92例为对照组,对比分析孕妇血清Th因子和HBV-DNA载量变化,比较新生儿出生时HBV DNA载量和乙肝抗原抗体阳性情况。结果治疗后,观察组孕妇血清INF-γ和IL-2显著高于对照组(P0.05),而IL-4、IL-6、HBV DNA阳性率、HBV DNA载量显著低于对照组(P0.05);观察组新生儿HBeAg阳性率、HBV DNA阳性率显著低于对照组(P0.05)。结论替比夫定能够改善HBeAg阳性CHB孕妇血清Th因子表达水平,降低HBV DNA载量,对于阻断CHB母婴垂直传播具有重要意义。
[Abstract]:Objective to observe the changes of serum helper T cell Th) and HBV DNA load in patients with hepatitis B E antigen (HBeAg) positive chronic hepatitis B (CHB) before and after tibivudine treatment, and to analyze the effect of tibivudine on mother-to-child transmission of CHB. Methods 92 HBeAg positive CHB pregnant women who received tibivudine therapy in hospital from August 2013 to July 2015 were selected as observation group and 92 HBeAg positive CHB pregnant women who received hepatoprotective therapy as control group. The changes of serum Th factor and HBV-DNA load in pregnant women were compared and analyzed. To compare the HBV DNA load and HBV antibody positive rate at birth. Results after treatment, the serum levels of INF- 纬 and IL-2 in the observation group were significantly higher than those in the control group (P 0.05), while the positive rate of IL-4 / IL-6 / HBV DNA was significantly lower than that in the control group (P 0.05), and the positive rate of HBeAg and HBV DNA in the observation group was significantly lower than that in the control group (P 0.05). Conclusion tibivudine can improve serum Th factor expression and decrease HBV DNA load in HBeAg-positive CHB pregnant women. It is of great significance to block vertical transmission of CHB from mother to child.
【作者单位】：平顶山市第一人民医院妇产科;南昌大学玛丽女王学院中英临床系;鲁山县张官营镇中心医院;平顶山市卫东区东高皇乡卫生院;平顶山市第一人民医院急诊科;
【分类号】：R714.251

【相似文献】