PNPLA3 rs738409基因多态性与丙型肝炎脂肪肝及肝纤维化相关性研究的meta分析

发布时间：2018-06-29 13:55

本文选题：PNPLA3 + rs738409基因多态性　；参考：《重庆医科大学》2016年硕士论文

【摘要】：背景:目前,全世界有近3%的人口感染了丙型肝炎病毒,其中大约80%为慢性感染;慢性丙型肝炎感染已成为因肝脏疾病导致死亡的主要原因。根据近年来的研究进展,遗传危险因素已被确定在慢性丙型肝炎相关的肝脏疾病进展中起到了关键的作用,其中马铃薯糖蛋白样磷脂酶蛋白3(PNPLA3)rs738409基因多态性已成为这一领域的研究热点。然而,该位点基因多态性是否与丙型肝炎脂肪肝及纤维化相关还没有达成共识。目的:通过全面的文献检索和严格的筛选,对纳入的相关原始文献进行meta分析,来探讨PNPLA3 rs738409基因多态性与丙型肝炎脂肪肝及肝纤维化的相关性。方法:我们对PubMed,EMBASE,Web of Science和谷歌学术数据库进行了全面的文献检索,数据库更新日期为2014年12月31日;通过计算比值比(ORs)和95%的可信区间(CIs)来探讨PNPLA3rs738409基因多态性与丙型肝炎脂肪肝及肝纤维化的相关性;用STATA12.0软件来进行统计分析的计算。结果:通过对纳入的文献进行meta分析,我们发现在高加索人群中,慢丙肝患者GG基因型与CC+CG相比有较高的重度肝纤维化的患病风险(OR,2.51;95%CI,1.75-3.60;P0.05);然而,在亚洲人群中没有观察到这种相关性(OR,1.31;95%CI,0.65-2.67;P=0.457);在高加索人群中,慢性丙型肝炎患者GG基因型与CC+CG相比也有较高的脂肪肝的患病风险(OR,4.33;95%CI:2.59-7.22;P0.05);敏感性分析结果显示,本篇meta分析结果稳定,没有发现明显的发表偏倚。结论:通过本篇meta分析,我们得出结论,在高加索人群中,PNPLA3 rs738409基因多态性与丙型肝炎脂肪肝及重度肝纤维化均有明显相关性。
[Abstract]:Background: at present, nearly 3% of the world's population is infected with hepatitis C virus, about 80% of which is chronic infection, chronic hepatitis C infection has become the main cause of death due to liver disease. Based on recent advances in research, genetic risk factors have been identified to play a key role in the progression of liver diseases associated with chronic hepatitis C. The polymorphism of Potato glycoprotein like phospholipase 3 (PNPLA3) rs738409 gene has become a hotspot in this field. However, there is no consensus on whether this locus polymorphism is associated with hepatitis C fatty liver and fibrosis. Objective: to investigate the relationship between the polymorphism of PNPLA3 rs738409 gene and fatty liver and hepatic fibrosis in hepatitis C. Methods: we conducted a comprehensive literature search on PubMedus EMBASEN Web of Science and Google academic database, the date of updating the database was December 31, 2014; The correlation of PNPLA3rs738409 gene polymorphism with hepatitis C fatty liver and hepatic fibrosis was studied by calculating ratio (ORs) and 95% confidence interval (CIs). Results: by meta analysis of the literature included, we found that GG genotype of chronic hepatitis C patients had a higher risk of severe hepatic fibrosis than CC CG in Caucasian population (OR2.51 95% CII 1.75-3.60 P 0.05); however, This correlation was not observed in the Asian population (OR1. 31 / 95 CIQ 0.65-2.67 P0. 457), and the GG genotype in patients with chronic hepatitis C also had a higher risk of fatty liver disease compared with CC CG in the Caucasian population (OR4. 33 + 95 CI: 2.59-7.22P0.05), and the sensitivity analysis showed that the results of this meta analysis were stable, the results of the sensitivity analysis showed that the GG genotypes of the patients with chronic hepatitis C also had a higher risk of fatty liver disease than that of CC CG. No apparent publication bias was found. Conclusion: by meta analysis, we conclude that the polymorphism of PNPLA3 rs738409 gene is associated with fatty liver and severe hepatic fibrosis in Caucasian population.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R512.63;R575

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