TCF7L2基因rs3814570多态性与新疆维吾尔族人群T2DM的相关性研究

发布时间：2018-07-15 21:09

【摘要】：目的探讨新疆地区维吾尔族人群转录因子7类似物2(TCF7L2)基因的rs3814570位点与2型糖尿病(T2DM)的相关性。方法采用病例-对照研究设计,以经确诊的949例T2DM患者作为观察组,选取963例健康体检者作为对照组。应用基质辅助激光解吸附电离飞行时间质谱分析质谱技术(MALDI-TOF)对TCF7L2基因多态性进行检测。结果两组对象rs3814570位点基因型CC、CT和TT,等位基因C和T的分布比较,差异有统计学意义(P0.05),CT基因型携带者患T2DM的风险是CC基因型携带者的0.331倍(OR=0.331,95%CI:0.166~0.661,P=0.002),TT基因型携带者患T2DM的风险是CC基因型携带者的0.539倍(OR=0.539,95%CI:0.348~0.834,P=0.005),T等位基因携带者患T2DM的风险是C等位基因携带者的0.501倍(OR=0.501,95%CI:0.377~0.664,P0.01)。两组对象中,TCF7L2基因rs3814570位点的CT+TT基因型组的空腹血糖(FPG)水平均明显低于CC基因型组(P0.05)。结论 TCF7L2基因的rs3814570位点可能与新疆维吾尔族人群T2DM的发生相关,T等位基因和TT基因型可能是T2DM发生的保护因素。
[Abstract]:Objective to investigate the relationship between rs3814570 locus of transcription factor 7 analogue 2 (TCF7L2) gene and type 2 diabetes mellitus (T2DM) in Uygur population of Xinjiang. Methods 949 patients with T2DM were selected as observation group and 963 healthy persons as control group. Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF) was used to detect the polymorphism of TCF7L2 gene. Results the distribution of rs3814570 locus genotype CCT and TTT, allele C and T were compared between the two groups. The difference was statistically significant (P0.05) the risk of T2DM in T2DM carriers was 0.331 times higher than that in CC genotype carriers (OR 0.331T 95 CI 0.166U 0.661U P0.002). The risk of T2DM in T2DM carriers with TT genotype was 0.539 times higher than that with CC genotype carriers (ORO 0.53995 CIW 0.3480.834P0.005) and T allele carriers with T2DM were 0.539 times more likely to develop T2DM than those with CC genotype (ORO 0.53995 CIW 0.3480.834P0.005). The risk of T2DM in T2DM carriers with TT genotype was 0.539 times higher than that with CC genotype carriers. 0.501 times as much as the carrier of the gene (ORX 0.501 / 95 CI: 0.3770.664P0.01). The fasting blood glucose (FPG) levels in CTTT genotype group were significantly lower than those in CC genotype group (P0.05) in the rs3814570 locus of TCF7L2 gene in both groups. Conclusion the rs3814570 locus of TCF7L2 gene may be associated with the occurrence of T2DM in Xinjiang Uygur population and the T allele and TT genotype may be the protective factors of T2DM.
【作者单位】：新疆医科大学公共卫生学院;新疆医科大学第一附属医院内分泌科;新疆医科大学第一附属医院代谢性疾病重点实验室;
【基金】：国家重点基础研究发展计划(973计划)资助项目(2012CB722403)
【分类号】：R587.1

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