家蚕凋亡相关基因研究进展

发布时间：2018-08-03 12:14

【摘要】：细胞凋亡指细胞受基因调控的自主的细胞死亡过程,是细胞为维持内环境稳态的一种手段。家蚕Bombyx mori是重要的鳞翅目模式昆虫,对其细胞凋亡机制的研究具有代表性。家蚕细胞凋亡不仅参与了整个变态发育过程,而且在家蚕天然免疫反应中扮演着重要角色。在家蚕卵-幼虫-蛹-成虫各阶段通过凋亡基因的调控促进组织退化及冗余细胞的清除,并且在家蚕抗家蚕核型多角体病毒(Bm NPV)过程中,细胞凋亡的发生对Bm NPV增殖的抑制也有着重要作用。本文就近年来家蚕细胞凋亡诱导因素、细胞凋亡相关基因的研究现状及通路和细胞凋亡对家蚕发育影响的研究进展进行综述,为解决目前家蚕细胞凋亡机制研究不足、内质网通路涉猎少、各通路间联系不清晰等问题,以及深入研究家蚕细胞凋亡并解析家蚕变态发育机制和天然免疫反应提供参考。
[Abstract]:Apoptosis refers to the process of cell death, which is controlled by genes, and is a means of maintaining homeostasis. Bombyx mori Bombyx mori is an important Lepidoptera model insect. Apoptosis not only plays an important role in the process of metamorphosis, but also plays an important role in the innate immune response of Bombyx mori. In different stages of home silkworm eggs, larva and pupae, apoptosis gene regulation promotes tissue degeneration and the elimination of redundant cells, and during the process of silkworm resistance to Bombyx mori nuclear polyhedrosis virus (Bm NPV). Apoptosis also plays an important role in inhibiting the proliferation of BM NPV. In this paper, the research progress of apoptosis inducing factors, apoptosis-related genes and pathways and the effects of apoptosis on the development of silkworm were reviewed in order to solve the problem of the mechanism of apoptosis in silkworm, Bombyx mori (Bombyx mori). The endoplasmic reticulum pathway is less accessible and the connections between the pathways are not clear. Further studies on the apoptosis of silkworm cells and analysis of the mechanism of metamorphosis and innate immune response of silkworm provide references.
【作者单位】：家蚕基因组生物学国家重点实验室农业部蚕桑生物学与遗传育种重点实验室;重庆市蚕业管理总站;
【基金】：国家自然科学基金项目(31602009,31572466,31472152) 中国博士后科学基金面上项目(2015M582502)
【分类号】：S881.2

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