北京市2016年发现流行性腮腺炎G基因型病毒
发布时间：2018-08-17 11:21
【摘要】：通过对北京市2004~2016年流行性腮腺炎的流行特征、病毒监测及SH基因序列的分析,与我国其他省份及全球参考病毒株序列进行同源性比较,阐述北京市腮腺炎病毒基因型分布和变异情况,报告新发现的G基因型病毒与我国其他地区病毒的相似性。研究发现从2007年随有免疫史病例增多病毒分离率明显下降,2010~2016年下降到10%以下。2016年分离到3株腮腺炎病毒,2株得到基因分型结果其中一株为F基因型,另一株G基因型。G基因型病毒与2011年陕西省流行的G基因型病毒最为接近。2004年至今,F基因型病毒一直为北京本地流行株。北京将腮腺炎纳入免疫规划后,随着本地优势流行病毒株的减少,发现了其他基因型病毒,因此应加强病毒监测,尽早发现并阻断新的病毒传播链。
[Abstract]:The epidemic characteristics, virus surveillance and SH gene sequence of mumps in Beijing from 2004 to 2016 were compared with those of other provinces in China and the global reference virus strains. This paper describes the distribution and variation of mumps virus genotypes in Beijing, and reports the similarity between the newly discovered G genotype virus and other viruses in other regions of China. It was found that the isolation rate of mumps virus decreased significantly from 2007 to 2016 with the increase of cases with immunological history. In 2016, 3 mumps virus strains and 2 strains of mumps virus strains were genotyped, one of which was genotype F. The other G genotype. G genotype virus is the most close to the 2011 G genotype virus in Shaanxi Province, and the F genotype virus has been the endemic strain in Beijing since 2004. After mumps was included in the immunization program, other genotypes were found with the decrease of local dominant epidemic virus strains. Therefore, virus surveillance should be strengthened to detect and block the new virus transmission chain as soon as possible.
【作者单位】： 北京市疾病预防控制中心北京市预防医学研究中心;中国疾病预防控制中心病毒病预防控制所;北京市大兴区疾病预防控制中心;
【基金】：北京市自然科学基金(项目号:7172105),题目:流行性腮腺炎疫苗免疫策略及有免疫史病例发病原因研究 国家科技重大专项(项目号:2016ZX10004206),题目:艾滋病和病毒性肝炎等重大传染病防治~~
【分类号】：R373
本文编号：2187469
[Abstract]:The epidemic characteristics, virus surveillance and SH gene sequence of mumps in Beijing from 2004 to 2016 were compared with those of other provinces in China and the global reference virus strains. This paper describes the distribution and variation of mumps virus genotypes in Beijing, and reports the similarity between the newly discovered G genotype virus and other viruses in other regions of China. It was found that the isolation rate of mumps virus decreased significantly from 2007 to 2016 with the increase of cases with immunological history. In 2016, 3 mumps virus strains and 2 strains of mumps virus strains were genotyped, one of which was genotype F. The other G genotype. G genotype virus is the most close to the 2011 G genotype virus in Shaanxi Province, and the F genotype virus has been the endemic strain in Beijing since 2004. After mumps was included in the immunization program, other genotypes were found with the decrease of local dominant epidemic virus strains. Therefore, virus surveillance should be strengthened to detect and block the new virus transmission chain as soon as possible.
【作者单位】： 北京市疾病预防控制中心北京市预防医学研究中心;中国疾病预防控制中心病毒病预防控制所;北京市大兴区疾病预防控制中心;
【基金】：北京市自然科学基金(项目号:7172105),题目:流行性腮腺炎疫苗免疫策略及有免疫史病例发病原因研究 国家科技重大专项(项目号:2016ZX10004206),题目:艾滋病和病毒性肝炎等重大传染病防治~~
【分类号】：R373
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