白血病慢粒急变过程相关基因的生物信息及临床分析
发布时间：2018-08-18 13:56
【摘要】：急性粒细胞白血病(AML)是一种白细胞异常生长并积累从而干扰正常血细胞生长的恶性肿瘤。迄今为止,急性粒细胞白血病是如何由慢性粒细胞白血病转化的机制仍不清楚。本研究中,我们发现长链非编码RNA FAM30A在慢性粒细胞白血病(CML)的加速期和急变期均表达较高,而在CML的慢性期表达较低。在对急性粒细胞白血病的患者的临床流行病学分析中,FAM30A的表达量是与总生存时间显著相关的预后因子,且在多变量分析时,当调节了多个危险因素后,FAM30A过表达仍与患者生存时间呈显著负相关。进一步研究表明,在年龄小于60岁的AML患者和正常核型的AML患者中,FAM30A高表达的病人预后均较差。我们的研究结果表明,FAM30A可作为急性粒细胞白血病的一个独立预后因子,将为研究慢粒急粒变病理机制提供重要理论根据。
[Abstract]:Acute myeloid leukemia (AML) is a malignant tumor with abnormal growth and accumulation of leukocytes, which interferes with the growth of normal blood cells. So far, the mechanism of transformation of acute myeloid leukemia from chronic myeloid leukemia remains unclear. In this study, we found that the expression of long chain noncoding RNA FAM30A was higher in the accelerated and acute phase of chronic myeloid leukemia (CML), but lower in the chronic phase of CML. In the clinical epidemiological analysis of patients with acute myeloid leukemia, the expression of FAM30A was a prognostic factor significantly related to the total survival time, and in multivariate analysis, After adjusting multiple risk factors, the overexpression of FAM30A was negatively correlated with survival time. Further studies showed that the prognosis of patients with high expression of FAM30A was poor in both AML patients under 60 years old and AML patients with normal karyotype. Our results suggest that FAM30A may be an independent prognostic factor for acute myeloid leukemia, which will provide an important theoretical basis for the study of the pathological mechanism of chronic granulocytosis.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R733.7
本文编号：2189679
[Abstract]:Acute myeloid leukemia (AML) is a malignant tumor with abnormal growth and accumulation of leukocytes, which interferes with the growth of normal blood cells. So far, the mechanism of transformation of acute myeloid leukemia from chronic myeloid leukemia remains unclear. In this study, we found that the expression of long chain noncoding RNA FAM30A was higher in the accelerated and acute phase of chronic myeloid leukemia (CML), but lower in the chronic phase of CML. In the clinical epidemiological analysis of patients with acute myeloid leukemia, the expression of FAM30A was a prognostic factor significantly related to the total survival time, and in multivariate analysis, After adjusting multiple risk factors, the overexpression of FAM30A was negatively correlated with survival time. Further studies showed that the prognosis of patients with high expression of FAM30A was poor in both AML patients under 60 years old and AML patients with normal karyotype. Our results suggest that FAM30A may be an independent prognostic factor for acute myeloid leukemia, which will provide an important theoretical basis for the study of the pathological mechanism of chronic granulocytosis.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R733.7
【参考文献】
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1 滕晓坤;肖华胜;;基因芯片与高通量DNA测序技术前景分析[J];中国科学(C辑:生命科学);2008年10期
，本文编号：2189679
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