基因多态性与奥氮平临床疗效相关性的研究进展

发布时间：2018-09-07 19:22

【摘要】：目的:了解基因多态性与奥氮平(OLA)临床疗效的相关性,为OLA个体化给药方案的制订提供参考。方法:查阅近年来国内外相关文献,就OLA代谢酶和作用靶点编码基因的多态性与其疗效相关性的研究进行归纳和总结。结果:参与OLA代谢的各个酶系编码基因的多态性均可影响药物在体内的代谢及药物浓度,从而进一步影响疗效,但相关结论仍然存在争议。这可能因为基因多态性对OLA疗效的影响由多个基因或某些基因之间的连锁平衡所决定,因此代谢酶的基因多态性与OLA临床疗效的关系仍需进一步研究探讨。而OLA作用靶点多巴胺受体(DR)基因多态性则影响OLA的应答时间以及体内的催乳素水平,五羟色胺受体(5-HTR)基因多态性与OLA改善精神分裂症致体质量增加存在相关性。结论:DR、5-HTR相关基因的多态性对OLA临床疗效及不良反应的存在不可忽视的影响。临床制订OLA治疗方案时需要考虑代谢酶和作用靶点基因多态性对其疗效的影响。
[Abstract]:Objective: to investigate the relationship between gene polymorphism and clinical efficacy of olanzapine (OLA), and to provide reference for the formulation of individual administration regimen for OLA. Methods: the correlation between the polymorphism of OLA metabolic enzyme and target coding gene and its therapeutic effect was summarized and summarized by referring to the relevant literatures at home and abroad in recent years. Results: the polymorphism of various enzyme coding genes involved in OLA metabolism can affect drug metabolism and drug concentration in vivo, thus further affecting the efficacy, but the relevant conclusions are still controversial. This may be because the effect of gene polymorphism on the efficacy of OLA is determined by the linkage equilibrium between multiple genes or some genes. Therefore, the relationship between gene polymorphisms of metabolic enzymes and the clinical efficacy of OLA needs to be further studied. The polymorphism of (DR) gene of dopamine receptor (DR), a target of OLA, affects the response time of OLA and prolactin level in vivo. The polymorphism of 5-HTR gene is associated with the improvement of body mass caused by OLA in schizophrenia. Conclusion the polymorphism of the 5-HTR-related gene in OLA can not be ignored in the clinical efficacy and adverse reactions of OLA. The effect of metabolic enzyme and target gene polymorphism on the therapeutic effect of OLA should be taken into account.
【作者单位】：南京大学医学院附属鼓楼医院药学部;中国药科大学基础医学与临床药学学院;
【基金】：江苏省药学会-Shire生物药学基金科研项目(No.S201607)
【分类号】：R969

【相似文献】