326例尖锐湿疣患者肛门及肛管组织HPV基因型检测及性别对比研究
发布时间：2018-10-14 19:36
【摘要】：目的国内有关肛门及肛管尖锐湿疣(CA)组织HPV分型研究的大样本资料报道极少。文中旨在探讨以江苏省为主的区域性男女肛门及肛管CA组织中HPV感染基因型分布状况和分型的临床意义。方法收集1985年8月至2017年7月江苏省和安徽省4家医院病理组织学诊断为两性肛门及肛管乳头瘤样增生伴挖空细胞(疑似CA)的石蜡组织标本326例。从其CA组织中抽提HPV DNA,对HPV感染型别分布状况进行分析。结果 326例两性肛门及肛管CA患者中,HPV总检出率为74.85%(244/326)。其中女147例,男179例,HPV总检出率分别为73.47%、75.98%。两性肛门及肛管CA组织阳性者检出不同型别HPV出现频数合计342次,低危型HPV出现频数合计267次,高危型HPV出现频数合计75次。其中6、11、16、18型HPV感染频数占前4位。30岁以下女性CA发病率较男性显著升高(32.65%vs 16.20%,P0.05)。结论两性肛门及肛管CA组织中,以6、11、16、18型HPV感染最为常见;30岁以下女性CA发病率较高,应引起疾病预防和临床诊治的高度重视。
[Abstract]:Objective there are few reports on (CA) HPV classification of anal and anal condyloma acuminatum in China. The purpose of this study was to investigate the distribution and clinical significance of genotypes of HPV infection in anal and anal CA tissues of men and women in Jiangsu Province. Methods from August 1985 to July 2017, 326 paraffin tissue specimens of anal and anal papilloma-like hyperplasia with hollow cells (suspected CA) were collected from 4 hospitals in Jiangsu Province and Anhui Province. HPV DNA, was extracted from its CA tissue to analyze the distribution of HPV infection types. Results the total detection rate of HPV was 74.85% (244 / 326) in 326 patients with anus and anal canal CA. Among them, 147 cases were female, 179 cases were male, the total detection rate of HPV was 73.47 and 75.98 respectively. The frequency of different types of HPV was 342 times in patients with positive CA tissue in anus and anal canal, 267 times in low risk type HPV and 75 times in high risk type HPV. The frequency of HPV infection in women under 30 years old was significantly higher than that in men (32.65%vs 16.20 P 0.05). Conclusion among the CA tissues of anus and anal canal of both sexes, the most common type of HPV infection is 6111116, and the incidence of CA is higher in women under 30 years old, which should be paid more attention to in the prevention of disease and clinical diagnosis and treatment.
【作者单位】： 南京中医药大学第三附属医院全国肛肠医疗中心;南京中医药大学第三附属医院病理科;周口市中医院皮肤科;中国医学科学院北京协和医学院皮肤病医院理疗科;
【基金】：江苏省南京市卫计委中医专项支助项目(2009-92)
【分类号】：R752.53
本文编号：2271440
[Abstract]:Objective there are few reports on (CA) HPV classification of anal and anal condyloma acuminatum in China. The purpose of this study was to investigate the distribution and clinical significance of genotypes of HPV infection in anal and anal CA tissues of men and women in Jiangsu Province. Methods from August 1985 to July 2017, 326 paraffin tissue specimens of anal and anal papilloma-like hyperplasia with hollow cells (suspected CA) were collected from 4 hospitals in Jiangsu Province and Anhui Province. HPV DNA, was extracted from its CA tissue to analyze the distribution of HPV infection types. Results the total detection rate of HPV was 74.85% (244 / 326) in 326 patients with anus and anal canal CA. Among them, 147 cases were female, 179 cases were male, the total detection rate of HPV was 73.47 and 75.98 respectively. The frequency of different types of HPV was 342 times in patients with positive CA tissue in anus and anal canal, 267 times in low risk type HPV and 75 times in high risk type HPV. The frequency of HPV infection in women under 30 years old was significantly higher than that in men (32.65%vs 16.20 P 0.05). Conclusion among the CA tissues of anus and anal canal of both sexes, the most common type of HPV infection is 6111116, and the incidence of CA is higher in women under 30 years old, which should be paid more attention to in the prevention of disease and clinical diagnosis and treatment.
【作者单位】： 南京中医药大学第三附属医院全国肛肠医疗中心;南京中医药大学第三附属医院病理科;周口市中医院皮肤科;中国医学科学院北京协和医学院皮肤病医院理疗科;
【基金】：江苏省南京市卫计委中医专项支助项目(2009-92)
【分类号】：R752.53
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