食管鳞癌中EGFR、HER-2、PIK3CA、P53基因突变与预后研究

发布时间：2018-10-31 09:04

【摘要】：目的:对比分析食管鳞癌中EGFR、HER-2、PIK3CA、P53基因突变情况,探讨基因检测在食管鳞癌患者中的临床应用价值及预后分析。方法:收集2013年1月至2015年12月在福建医科大学附属第一医院就诊的112例食管癌患者EGFR、HER-2、PIK3CA、P53基因检测的临床资料,根据基因分型分为EGFR、PIK3CA、HER-2和P53共4个组,对比不同的基因突变在性别、年龄、部位、吸烟、饮酒、淋巴结转移、分化程度、临床分期之间的差异。结果:112例食管癌中,EGFR基因突变4例(3.6%)、HER-2基因突变3例(2.8%)、PIK3CA基因突变7例(6.3%)、P53基因突变66例(58.9%)。EGFR基因突变与淋巴结转移有明显相关(p0.05),而与性别、年龄、部位、吸烟、饮酒、分化程度、临床分期无明显相关(p0.05)。HER-2基因突变与部位、淋巴结转移、分化程度、临床分期有明显相关(p0.05),与年龄可疑相关(p=0.051),而与性别、吸烟、饮酒无明显相关(p0.05)。PIK3CA基因突变与年龄、吸烟、临床分期有明显相关(p0.05),而与性别、部位、饮酒、淋巴结转移、分化程度无明显相关(p0.05)。P53基因突变与吸烟有明显相关(p0.05),而与性别、年龄、部位、饮酒、淋巴结转移、分化程度、临床分期无明显相关(p0.05)。食管癌中EGFR、PIK3CA、HER-2和P53基因突变无明显相关性(p0.05)。结论:食管鳞癌中EGFR、HER-2、PIK3CA、P53基因突变与食管癌的发生发展密切相关,基因检测在食管鳞癌的早期筛查、诊断及预后评估中有着重要意义。食管癌中EGFR基因突变与淋巴结转移有明显相关(p0.05),HER-2基因突变与部位、淋巴结转移、分化程度、临床分期有明显相关(p0.05),PIK3CA基因突变与年龄、吸烟、临床分期有明显相关(p0.05),P53基因突变与吸烟有明显相关(p0.05),故对EGFR、HER-2、PIK3CA基因进行检测对食管癌患者来说有更大的意义,便于早期发现高危患者,及时进行干预,提高患者的生存率和生存质量。
[Abstract]:Objective: to investigate the clinical value and prognosis of EGFR,HER-2,PIK3CA,P53 gene mutation in esophageal squamous cell carcinoma. Methods: the clinical data of EGFR,HER-2,PIK3CA,P53 gene detection in 112 patients with esophageal cancer from January 2013 to December 2015 in the first affiliated Hospital of Fujian Medical University were collected and divided into EGFR,PIK3CA, according to the genotyping. There were four groups of HER-2 and p53. The differences of gene mutation in sex, age, location, smoking, drinking, lymph node metastasis, differentiation and clinical stage were compared. Results: EGFR gene mutation was found in 4 cases (3.6%), HER-2 gene mutation in 3 cases (2.8%) and PIK3CA gene mutation in 7 cases (6.3%). The mutation of p53 gene was associated with lymph node metastasis in 66 cases (58.9%), but it was associated with sex, age, location, smoking, drinking and differentiation. There was no significant correlation between HER-2 gene mutation and location, lymph node metastasis, differentiation, clinical stage (p0. 05), age (p 0. 051), sex, smoking. There was no significant correlation between PIK3CA gene mutation and age, smoking, clinical stage (p0. 05), but gender, location, drinking, lymph node metastasis. There was no significant correlation between p53 gene mutation and smoking (p0.05), but not with sex, age, location, drinking, lymph node metastasis, differentiation and clinical stage (p0.05). There was no significant correlation between EGFR,PIK3CA,HER-2 and p53 gene mutation in esophageal carcinoma (p0. 05). Conclusion: the mutation of EGFR,HER-2,PIK3CA,P53 gene in esophageal squamous cell carcinoma is closely related to the occurrence and development of esophageal carcinoma. Gene detection plays an important role in early screening, diagnosis and prognosis evaluation of esophageal squamous cell carcinoma. There was a significant correlation between EGFR gene mutation and lymph node metastasis (p0.05), HER-2 gene mutation and location, lymph node metastasis, differentiation degree, clinical stage (p0.05), PIK3CA gene mutation and age, smoking. There was a significant correlation between the clinical stages (p0.05), p53 gene mutation and smoking (p0.05). Therefore, the detection of EGFR,HER-2,PIK3CA gene has more significance for esophageal cancer patients, so it is convenient to find high-risk patients early. Timely intervention to improve the survival rate and quality of life of patients.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R735.1

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