肺腺癌组织中TTF-1表达变化及其与EGFR基因突变、患者预后的关系

发布时间：2018-12-13 17:32

【摘要】：目的观察肺腺癌组织甲状腺转录因子1(TTF-1)表达变化,并分析其与表皮生长因子受体(EGFR)基因突变、患者预后的关系。方法肺腺癌患者192例,观察其TTF-1表达变化及EGFR基因突变情况,分析TTF-1阳性表达、EGFR基因突变与肺腺癌临床病理参数的关系,另采用Kaplan-Meier生存分析、Log Rank检验及Cox风险回归模型分析影响患者预后的因素。结果 192例患者中,TTF-1阳性表达157例(81.8%)、阴性表达35例(18.2%),EGFR基因突变型80例(41.7%)、野生型112例(58.3%)。TTF-1阳性表达与肺腺癌TNM分期相关,EGFR基因突变与肺腺癌患者性别、吸烟史相关,P均0.05。157例TTF-1阳性患者中有79例(50.3%)发生EGFR基因突变,而35例TTF-1阴性患者中仅有1例(2.9%)发生EGFR基因突变,TTF-1阳性表达与EGFR突变有相关性(P0.05)。单因素生存分析显示,TTF-1阳性、EGFR基因突变、年龄、PS评分、TNM分期与患者预后相关(P均0.05)。多因素生存分析显示,TTF-1阳性、EGFR基因突变、TNM分期早期、PS评分0~2分是肺腺癌远期生存的独立影响因素(P均0.05)。结论检测肺腺癌组织TTF-1表达情况有助于初步预测肺腺癌EGFR基因突变状态及判断患者预后。
[Abstract]:Objective to investigate the changes of thyroid transcription factor 1 (TTF-1) expression in lung adenocarcinoma and its relationship with epidermal growth factor receptor (EGF) receptor (EGFR) gene mutation and prognosis. Methods the changes of TTF-1 expression and EGFR gene mutation were observed in 192 patients with lung adenocarcinoma. The positive expression of TTF-1, the relationship between EGFR gene mutation and clinicopathological parameters of lung adenocarcinoma were analyzed. Kaplan-Meier survival analysis was used. Log Rank test and Cox risk regression model were used to analyze the prognostic factors. Results TTF-1 positive expression was found in 157 cases (81.8%), negative expression in 35 cases (18.2%), EGFR gene mutation in 80 cases (41.7%). The positive expression of TTF-1 was correlated with the TNM stage of lung adenocarcinoma, and the mutation of EGFR gene was associated with sex and smoking history of lung adenocarcinoma. There were 79 cases (50.3%) with EGFR gene mutation in all patients with TTF-1 positive, while only 1 case (2.9%) had EGFR gene mutation in 35 TTF-1 negative patients. The positive expression of TTF-1 was correlated with EGFR mutation (P0.05). Univariate survival analysis showed that TTF-1 positive, EGFR gene mutation, age, PS score and TNM stage were correlated with the prognosis of the patients (all P 0. 05). Multivariate survival analysis showed that TTF-1 positive, EGFR gene mutation, early TNM stage, and PS score 0 ~ 2 were independent factors for long-term survival of lung adenocarcinoma (P 0.05). Conclusion detecting the expression of TTF-1 in lung adenocarcinoma is helpful to predict the mutation status of EGFR gene in lung adenocarcinoma and to judge the prognosis of lung adenocarcinoma.
【作者单位】：首都医科大学附属北京世纪坛医院;
【基金】：北京市卫生系统高层次卫生技术人才队伍建设专项经费北京市属医院科研培育计划项目(PX2016044) 北京世纪坛医院院青年基金资助项目(2015-q10)
【分类号】：R734.2

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