新疆维吾尔族非小细胞肺癌表皮生长因子受体基因突变与病理特征的相关性研究
发布时间：2018-12-17 19:43
【摘要】：目的研究新疆维吾尔族非小细胞肺癌(NSCLC)表皮生长因子受体(EGFR)基因突变与病理特征的相关性。方法回顾性分析2003年1月~2014年1月新疆喀什地区第二人民医院诊治的新疆维吾尔族NSCLC患者的组织蜡块43例,病理标本均予EGFR基因突变检测试剂盒检测,观察患者EGFR基因突变检出率、临床病症分型与EGFR基因突变的相关性,基线资料与EGFR基因突变的相关性。结果本组患者病理标本EGFR基因突变率为11.63%(5/43),第19外显子缺失改变率[80.00%(4/5)]显著高于第21外显子L858R点突变率[20.00%(1/5)](P0.01);临床病症分型中腺癌EGFR基因突变检出率[19.05%(4/21)]较鳞癌[6.67%(1/15)]、大细胞癌[0.00%(0/4)]及其他癌[0.00%(0/3)]高(P0.05),同时临床基线资料中女性EGFR基因突变检出率[20.00%(4/20)]较男性[4.34%(1/23)]高(P0.05)。在临床基线资料中年龄、吸烟史和TNM分期的EGFR基因突变检出率比较,差异无统计学意义(P0.05)。结论新疆维吾尔族NSCLC患者EGFR基因突变与病理特征具一定相关性,临床女性腺癌患者较多见。
[Abstract]:Objective to study the relationship between (NSCLC) epidermal growth factor receptor (EGFR) gene mutation and pathological features in Uygur non-small cell lung cancer (NSCLC). Methods from January 2003 to January 2014, 43 cases of NSCLC tissues from Xinjiang Uygur nationality treated by the second people's Hospital of Kashi region, Xinjiang, were retrospectively analyzed. All the pathological specimens were detected by EGFR gene mutation detection kit. The detection rate of EGFR gene mutation, the correlation between clinical symptom type and EGFR gene mutation, and the correlation between baseline data and EGFR gene mutation were observed. Results the mutation rate of EGFR gene was 11.63% (5 / 43). The deletion rate of exon 19 [80.00% (4 / 5)] was significantly higher than that of exon 21 L858R (20.00% (1 / 5) (P0.01). The detection rate of EGFR gene mutation in adenocarcinoma [19.05% (4 / 21)] was higher than that in squamous cell carcinoma [6.67% (1 / 15)]. Large cell carcinoma [0.00% (0 / 4)] and other cancers [0.00% (0 / 3)] were high (P0.05). At the same time, the detection rate of EGFR gene mutation in women [20.00% (4 / 20)] was higher than that in men [4.34% (1 / 23)] (P0.05). In clinical baseline data, there was no significant difference in the detection rate of EGFR gene mutation in age, smoking history and TNM stage (P0.05). Conclusion the mutation of EGFR gene in Xinjiang Uygur NSCLC patients is correlated with the pathological features.
【作者单位】： 新疆喀什地区第二人民医院肿瘤科;复旦大学附属肿瘤医院肿瘤内科;
【基金】：新疆维吾尔自治区科技支疆项目(2013911115)
【分类号】：R734.2
[Abstract]:Objective to study the relationship between (NSCLC) epidermal growth factor receptor (EGFR) gene mutation and pathological features in Uygur non-small cell lung cancer (NSCLC). Methods from January 2003 to January 2014, 43 cases of NSCLC tissues from Xinjiang Uygur nationality treated by the second people's Hospital of Kashi region, Xinjiang, were retrospectively analyzed. All the pathological specimens were detected by EGFR gene mutation detection kit. The detection rate of EGFR gene mutation, the correlation between clinical symptom type and EGFR gene mutation, and the correlation between baseline data and EGFR gene mutation were observed. Results the mutation rate of EGFR gene was 11.63% (5 / 43). The deletion rate of exon 19 [80.00% (4 / 5)] was significantly higher than that of exon 21 L858R (20.00% (1 / 5) (P0.01). The detection rate of EGFR gene mutation in adenocarcinoma [19.05% (4 / 21)] was higher than that in squamous cell carcinoma [6.67% (1 / 15)]. Large cell carcinoma [0.00% (0 / 4)] and other cancers [0.00% (0 / 3)] were high (P0.05). At the same time, the detection rate of EGFR gene mutation in women [20.00% (4 / 20)] was higher than that in men [4.34% (1 / 23)] (P0.05). In clinical baseline data, there was no significant difference in the detection rate of EGFR gene mutation in age, smoking history and TNM stage (P0.05). Conclusion the mutation of EGFR gene in Xinjiang Uygur NSCLC patients is correlated with the pathological features.
【作者单位】： 新疆喀什地区第二人民医院肿瘤科;复旦大学附属肿瘤医院肿瘤内科;
【基金】：新疆维吾尔自治区科技支疆项目(2013911115)
【分类号】：R734.2
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