肺炎型肺腺癌患者EGFR基因突变和ALK基因重排情况的临床分析

发布时间：2018-12-17 16:57

【摘要】：目的探讨肺炎型肺腺癌患者EGFR基因突变、ALK基因重排的特点及其临床意义。方法选取2016年1-8月第三军医大学新桥医院病理组织学确诊为肺腺癌患者154例为研究对象,根据影像学表现分为肺炎型(30例)、非肺炎型(124例)。154例患者均进行EGFR基因检测,其中87例患者同时进行ALK基因重排检测。比较肺炎型与非肺炎型肺腺癌患者EGFR基因突变率、ALK基因重排率及临床特征的关系。结果肺炎型组患者EGFR基因突变率为20.0%(6/30),非肺炎型组为47.6%(59/124),差异有统计学意义(P0.05)。两组年龄、吸烟史、性别、肿瘤家族史、ALK基因重排、TNM分期比较,差异无统计学意义(P0.05)。总体EGFR基因突变率为42.2%(65/154),吸烟史、性别与EGFR基因突变有关,年龄、肿瘤家族史与EGFR基因突变无明显相关性。总体ALK基因重排率为11.5%,吸烟史、肿瘤家族史、性别、年龄与ALK基因重排无明显相关性。87例同时行EGFR及ALK基因检测的患者,未发现EGFR基因突变、ALK基因重排共同存在的情况。结论影像学表现为肺炎型的肺腺癌患者,应同时行EGFR基因突变和ALK基因重排检测,以便为晚期肿瘤患者制定全面的全程管理方案。
[Abstract]:Objective to investigate the characteristics and clinical significance of EGFR gene mutation and ALK gene rearrangement in patients with pneumonic lung adenocarcinoma. Methods 154 patients with lung adenocarcinoma diagnosed by histopathology in Xinqiao Hospital of the third military Medical University from January to August 2016 were selected as the study subjects. According to the imaging findings, the patients were divided into pneumonia type (30 cases). EGFR gene was detected in 154 patients, and ALK gene rearrangement was detected in 87 patients at the same time. To compare the relationship of EGFR gene mutation rate, ALK gene rearrangement rate and clinical features between pneumonic and non-pneumonic lung adenocarcinoma patients. Results the mutation rate of EGFR gene was 20.0% (6 / 30) in pneumonia type group and 47.6% (59 / 124) in non-pneumonia type group (P0.05). There was no significant difference in age, smoking history, sex, cancer family history, ALK gene rearrangement and TNM stage between the two groups (P0.05). The total mutation rate of EGFR gene was 42.2% (65 / 154). Smoking history, sex and EGFR gene mutation were related to age, tumor family history and EGFR gene mutation. The overall ALK gene rearrangement rate was 11.5%. There was no significant correlation between smoking history, family history of cancer, sex, age and ALK gene rearrangement. No mutation of EGFR gene was found in 87 patients who underwent EGFR and ALK gene detection at the same time. The co-existence of ALK gene rearrangement. Conclusion EGFR gene mutation and ALK gene rearrangement should be detected simultaneously in lung adenocarcinoma patients with pneumonic manifestations in order to establish a comprehensive management scheme for advanced tumor patients.
【作者单位】：贵州省贵阳市第一人民医院呼吸内科;第三军医大学新桥医院呼吸内科;四川省岳池县中医医院内一科;
【分类号】：R734.2

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