杜仲预防UVB致人成纤维细胞光老化的作用及基因水平的机制探讨
发布时间:2018-12-19 07:10
【摘要】:以UVB辐射体外培养的人成纤维细胞,探讨了杜仲乙醇提取物乙酸乙酯萃取部分(简称杜仲提取物)预防人成纤维细胞光老化的作用,并利用基因芯片对其可能的作用机制进行了探索。实验结果表明,杜仲提取物可以减少UVB对人成纤维细胞活性的影响,具有较好的预防光老化的作用,且基因芯片结果提示这种防护作用可能与提高细胞的抗氧化、DNA修复、抗凋亡有关,同时可能还具有一定促进细胞增殖和预防黑素细胞瘤的作用。
[Abstract]:In this paper, the effects of ethyl acetate extract from ethanol extract of Eucommia ulmoides on the prevention of photoaging of human fibroblasts exposed to UVB radiation were studied. The possible mechanism of its action was explored by using gene chip. The results showed that the extract of Eucommia ulmoides could reduce the effect of UVB on the activity of human fibroblasts, and had a better effect on preventing photoaging. The results of gene chip indicated that the protective effect of Eucommia ulmoides extract might be related to the improvement of antioxidant activity and DNA repair of human fibroblasts. Anti-apoptosis may also promote cell proliferation and prevent melanoma.
【作者单位】: 上海家化联合股份有限公司技术中心;
【分类号】:R285;TQ658
本文编号:2386579
[Abstract]:In this paper, the effects of ethyl acetate extract from ethanol extract of Eucommia ulmoides on the prevention of photoaging of human fibroblasts exposed to UVB radiation were studied. The possible mechanism of its action was explored by using gene chip. The results showed that the extract of Eucommia ulmoides could reduce the effect of UVB on the activity of human fibroblasts, and had a better effect on preventing photoaging. The results of gene chip indicated that the protective effect of Eucommia ulmoides extract might be related to the improvement of antioxidant activity and DNA repair of human fibroblasts. Anti-apoptosis may also promote cell proliferation and prevent melanoma.
【作者单位】: 上海家化联合股份有限公司技术中心;
【分类号】:R285;TQ658
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