谷胱甘肽S-转移酶基因多态性与乳腺癌易感性关系的META分析

发布时间：2019-04-26 01:22

【摘要】：目的通过Meta分析方法,收集已有相关原始研究进行二次文献分析,评估GSTT1、GSTM1、GSTP1基因多态性与乳腺癌易感性的关系,为乳腺癌的预防及治疗提供循证医学证据。方法运用学校图书馆,通过主题词检索中英文目标数据库,并辅以引文文献追溯的方法筛选出符合纳入排除标准的文章。运用STATA 11.0对文章进行meta分析,用比值比(OR)及95%可信区间(95%CI)评估GST基因多态性与乳腺癌易感性的关联强度,并根据异质性选择固定或随机效应模型。用Begg's漏斗图和Egger's检验评估发表偏倚。同时通过累计meta分析揭示历年研究结果的趋势。结果共92篇关于GST基因多态性与乳腺癌易感性关系的文章纳入meta分析,其中有61篇文章关于GSTT1基因、76篇关于GSTM1基因、52篇关于GSTP1基因。合并meta分析结果显示,GSTT1及GSTM1基因的缺失突变可增加乳腺癌的发病风险(null vs. present:GSTT1 OR=1.21,95%CI: 1.11-1.32; I2=65.2%; GSTM1 OR=1.16,95%CI:1.09-1.24; I2=64.2%),而GSTP1的多态性与乳腺癌易感性无关(G/A:OR=1.03,95%CI:0.93-1.13, I2=87.6%; GG/AA:OR=1.02,95%CI:0.83-1.24, I2=82.8%; GG/AG+AA: OR=1.00,95%CI:0.841-1.20, I2=80.1%; GG+AG/AA:OR=1.05,95%CI: 0.93-1.20, I2=88.8%)。累计分析结果得出与合并结果一致结论。亚组分析显示：GSTT1、GSTM1、GSTP1基因多态性与乳腺癌易感性关系不受绝经状态及对照来源的影响；GSTT1、GSTM1、GSTP1基因多态性均可增加亚洲人乳腺癌易感性,而与非洲裔美国人乳腺癌易感性无关；GSTP1突变增加了符合H-W平衡组的患乳腺癌风险(OR=1.09,95%CI:1.01-1.18; I2=73.1%)结论GSTT1、GSTMl缺失突变可增加乳腺癌的发病风险,但可能存在种族差异；GSTP1的多态性与亚洲人的乳腺癌易感性有关,但需要更多大样本、高质量的研究加以揭示。
[Abstract]:Aim to investigate the relationship between GSTT1,GSTM1,GSTP1 gene polymorphism and breast cancer susceptibility by Meta analysis, and to provide evidence-based evidence for the prevention and treatment of breast cancer. Methods the target databases of Chinese and English were searched by the subject words in the school library, and the articles which met the inclusion exclusion criteria were screened out by the method of citation literature tracing. STATA 11.0 was used for meta analysis. The ratio (OR) and 95% confidence interval (95%CI) were used to evaluate the association intensity between GST gene polymorphism and breast cancer susceptibility. Fixed or random effect models were selected according to heterogeneity. The published bias was evaluated by Begg's funnel diagram and Egger's test. At the same time, the trend of research results was revealed by cumulative meta analysis. Results A total of 92 articles on the relationship between GST gene polymorphism and breast cancer susceptibility were included in meta analysis. Among them, 61 articles were about GSTT1 gene, 76 were about GSTM1 gene and 52 were about GSTP1 gene. In combination with meta analysis, deletion mutations of GSTT1 and GSTM1 genes increased the risk of breast cancer by (null vs. present:GSTT1 OR=1.21,95%CI: 1.11 / 1.32, I2 / 65.2% and GSTM1 OR=1.16,95%CI:1.09-1.24;. The polymorphism of GSTP1 was not associated with the susceptibility to breast cancer (1.03, 95%, 0.93, 87.6%, 82.8%, 82.8%, respectively), and the genetic polymorphism was not associated with breast cancer susceptibility (1.03%, 95%, 0.93%, 87.6%, 82.8%, respectively). GG/AG AA:OR= 1.00, 95% CI 0.841? 1. 20, I 2? 80.1%; GG AG/AA:OR=1.05,95%CI: 0.93? 1.20, I 2? 88. 8%). The cumulative analysis results are consistent with the combined results. Subgroup analysis showed that the relationship between GSTT1,GSTM1,GSTP1 gene polymorphism and breast cancer susceptibility was not affected by menopause status and control sources. GSTT1,GSTM1,GSTP1 gene polymorphism increased breast cancer susceptibility in Asian people, but not with African American breast cancer susceptibility. GSTP1 mutation increased the risk of breast cancer (OR=1.09,95%CI:1.01-1.18; I2 / 73.1%). Conclusion GSTT1,GSTMl deletion mutation may increase the risk of breast cancer, but there may be racial difference. The polymorphism of GSTP1 is associated with breast cancer susceptibility in Asians, but more large samples and high-quality studies are needed to reveal it.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.9

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