人工基因元件的生理学研究进展
发布时间：2019-06-13 17:14
【摘要】：按照工程学原理人工设计的基因元件应该是模块化的,同时具备可预测地组装和再利用的属性。然而,真正的细胞生理条件下各种层次的生理干涉效应会严重地阻碍人工基因元件的功能性组装,即大多数组装后的人工系统完全或部分丧失预设功能。我们提出合成生理学的概念,将其定义为研究和控制人工生命系统与底盘细胞生理系统相互作用的合成生物学分支领域。在此框架下,本文归纳了细胞生理系统与人工基因元件的相互干涉方式,并对表征和消除这种相互作用的技术方法和设计策略进行综述。
[Abstract]:Genetic elements designed artificially according to engineering principles should be modular and have predictable assembly and reuse properties. However, under the real cell physiological conditions, the physiological interference effects at various levels will seriously hinder the functional assembly of artificial gene elements, that is, most of the assembled artificial systems completely or partially lose their preset function. We propose the concept of synthetic physiology, which is defined as a branch of synthetic biology to study and control the interaction between artificial life system and chassis cell physiological system. In this framework, the interference between cell physiological system and artificial gene elements is summarized, and the technical methods and design strategies to characterize and eliminate this interaction are reviewed.
【作者单位】： 中国科学院微生物研究所中国科学院微生物生理与代谢重点实验室;中国科学院大学;
【基金】：国家自然科学基金(No.31470818)资助~~
【分类号】：Q78
本文编号：2498680
[Abstract]:Genetic elements designed artificially according to engineering principles should be modular and have predictable assembly and reuse properties. However, under the real cell physiological conditions, the physiological interference effects at various levels will seriously hinder the functional assembly of artificial gene elements, that is, most of the assembled artificial systems completely or partially lose their preset function. We propose the concept of synthetic physiology, which is defined as a branch of synthetic biology to study and control the interaction between artificial life system and chassis cell physiological system. In this framework, the interference between cell physiological system and artificial gene elements is summarized, and the technical methods and design strategies to characterize and eliminate this interaction are reviewed.
【作者单位】： 中国科学院微生物研究所中国科学院微生物生理与代谢重点实验室;中国科学院大学;
【基金】：国家自然科学基金(No.31470818)资助~~
【分类号】：Q78
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