泛发性脓疱型银屑病的致病易感基因
发布时间：2019-06-20 06:00
【摘要】：正泛发性脓疱型银屑病(generalized pustular psoriasis,GPP)是威胁生命的系统性炎症性皮肤病,目前对其发病原因尚不完全清楚。随着2011年Marrakchi等[1]首次报道家族性GPP的致病基因,近年来关于GPP的遗传背景研究越来越丰富。最近,IL36RN和CARD14两个基因被认为是GPP的致病易感基因。本文对泛发性脓疱型银屑病的致病易感基因及相关疾病进行综述。
[Abstract]:Positive generalized pustular psoriasis (generalized pustular psoriasis,GPP) is a life-threatening systemic inflammatory skin disease, the cause of which is not fully understood at present. With the first report of familial GPP genes by Marrakchi et al. [1] in 2011, the genetic background of GPP has become more and more abundant in recent years. Recently, IL36RN and CARD14 genes are considered to be pathogenic genes of GPP. In this paper, the pathogenic susceptible genes and related diseases of generalized pustular psoriasis are reviewed.
【作者单位】： 中国医学科学院北京协和医学院北京协和医院皮肤科;
【基金】：北京市自然科学基金(2152117)
【分类号】：R758.63
，
本文编号：2502995
[Abstract]:Positive generalized pustular psoriasis (generalized pustular psoriasis,GPP) is a life-threatening systemic inflammatory skin disease, the cause of which is not fully understood at present. With the first report of familial GPP genes by Marrakchi et al. [1] in 2011, the genetic background of GPP has become more and more abundant in recent years. Recently, IL36RN and CARD14 genes are considered to be pathogenic genes of GPP. In this paper, the pathogenic susceptible genes and related diseases of generalized pustular psoriasis are reviewed.
【作者单位】： 中国医学科学院北京协和医学院北京协和医院皮肤科;
【基金】：北京市自然科学基金(2152117)
【分类号】：R758.63
，
本文编号：2502995
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