数值研究血管内白细胞介导的黑色素瘤细胞粘附

发布时间：2018-03-27 07:13

本文选题：黑色素瘤细胞　切入点：准定常描述　出处：《水动力学研究与进展(A辑)》2017年05期

【摘要】：该文研究了中性粒白细胞介导肿瘤细胞粘附于血管内皮细胞的过程。以血液中的黑色素瘤细胞为例,考虑其与白细胞之间特殊的分子配对成键以及表面摩擦因素,采用准定常方法,数值模拟了黑色素瘤细胞在白细胞表面运动粘附的过程。在不同的来流剪切率下,黑色素瘤细胞在与白细胞接触过程中的动力学特性会有不同。由于这种生化键的存在,增加了黑色素瘤细胞与白细胞的接触时间。数值结果表明:在低来流剪切率时,黑色素瘤细胞与白细胞的接触时间增加了1倍;在高来流剪切率时,黑色素瘤细胞虽然会在某一位置脱离白细胞表面,但是他们的接触时间还是延长了58.6%。说明这种生化键的存在极大促进黑色素瘤细胞的粘附,提高了肿瘤转移的几率。
[Abstract]:The process of neutrophil mediated tumor cell adhesion to vascular endothelial cells was studied. Taking melanoma cells in blood as an example, the special molecular pairing bonding and surface friction factors between melanoma cells and leukocytes were considered. A quasi-stationary method was used to numerically simulate the adhesion of melanoma cells on the surface of white blood cells. The kinetic characteristics of melanoma cells in the process of contact with white blood cells will be different. Due to the existence of this biochemical bond, the contact time between melanoma cells and white blood cells is increased. The numerical results show that at low flow shear rate, The contact time between melanoma cells and white blood cells doubled; at high flow shear rates, melanoma cells may escape from the surface of white blood cells at a certain location. However, their exposure time was prolonged by 58.6%, indicating that the existence of this biochemical bond greatly promoted the adhesion of melanoma cells and increased the risk of tumor metastasis.
【作者单位】：上海交通大学工程力学系;
【基金】：国家自然科学基金项目(11372186) 高等学校博士学科点专项科研基金项目(20130073110059)~~
【分类号】：O35;R739.5

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