复方苦参注射液治疗食管恶性肿瘤临床应用特征:一项基于医院信息系统电子医疗数据的真实世界研究

发布时间：2018-03-06 11:00

  本文选题：复方苦参注射液　切入点：食管恶性肿瘤　出处：《中国中药杂志》2017年15期 　论文类型：期刊论文

【摘要】：运用医院信息管理系统电子医疗数据,解析真实世界复方苦参注射液治疗食管恶性肿瘤临床应用特征,为复方苦参注射液的临床合理应用提供参考借鉴。基于中国中医科学院中医临床基础医学研究所建立的,医院信息系统电子医疗数据大型集成数据仓库,对来自全国范围22家大型三甲医院使用复方苦参注射液治疗食管恶性肿瘤的2 550例患者电子医疗数据进行提取,对一般特征、诊断特征、品种用药剂量与疗程特征信息、品种联合用药特征、出院转归特征等进行基于频数与百分比的描述性分析。结果显示使用复方苦参注射液治疗食管恶性肿瘤的患者平均年龄62.3岁;男性多于女性;主要由心血管科、肿瘤科、消化内科入院;基于出院转归判定的总有效率47.15%;单次用药剂量以10~20 m L居多;疗程以4~7 d为主;常见联用药物包括地塞米松、复方氨基酸注射液、托烷司琼注射液、胸腺肽注射液、甲氧氯普胺片等。复方苦参注射液治疗食管恶性肿瘤的人群特征明确,符合食管恶性肿瘤疾病的一般规律;其真实世界治疗食管恶性肿瘤临床用药剂量、疗程范围基本符合品种说明书相关界定;临床联合用药类型较为广泛。
[Abstract]:Using the electronic medical data of hospital information management system, the clinical application characteristics of compound Sophora flavescens injection in the real world for the treatment of esophageal malignant tumor were analyzed. To provide reference for rational clinical application of compound Sophora flavescens injection. Based on the large integrated data warehouse of electronic medical data of hospital information system established by Institute of Clinical basic Medicine of Chinese Academy of traditional Chinese Medicine, The electronic medical data of 2 550 patients with esophageal malignant tumor treated with compound Sophora flavescens injection from 22 large hospitals in China were extracted. The information of general characteristics, diagnostic characteristics, dosage and course of treatment were analyzed. The results showed that the average age of patients with esophageal malignant tumor treated with compound Sophora flavescens injection was 62.3 years old, male was more than female; The total effective rate based on the outcome of discharge was 47.15%. The single dose was 10 ~ 20 mL, the course of treatment was mainly 4 ~ 7 days. The common combined drugs included dexamethasone and compound amino acid injection. Tropisetron injection, thymic peptide injection, methoxyclopramide tablets, etc. The characteristics of compound Sophora flavescens injection in the treatment of esophageal malignant tumor were clear, which accord with the general law of esophageal malignant tumor disease. The range of clinical dosage for treatment of esophageal malignant tumors in the real world is basically in accordance with the relevant definition of the description of varieties, and the types of clinical combined use are more extensive.
【作者单位】： 中国中医科学院中医临床基础医学研究所;中国中医科学院望京医院;中国人民大学统计学院;中国人民解放军海军总医院;
【基金】：国家“重大新药创制”科技重大专项(2015ZX09501004-001-002,2015ZX09501004-001-009) 北京市中医药科技发展专项(JJ2014-53) 中国中医科学院自主选题项目(Z0472,PY1303)
【分类号】：R273;TP311.13
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本文编号：1574553