老龄人群甲状腺功能与身体成分的相关性分析

发布时间：2018-01-23 23:16

本文关键词： 正常甲状腺功能甲状腺激素老龄人群身体成分　出处：《南京医科大学学报(自然科学版)》2017年05期 　论文类型：期刊论文

【摘要】：目的 :探索老龄人群中甲状腺激素与肌肉及脂肪等身体成分的内在联系。方法 :74例年龄≥60岁的甲状腺功能正常的健康体检者,平均年龄(74.6±7.7)岁,测定其体重、甲状腺功能及身体成分等。结果:游离三碘甲状腺原氨酸(free triiodothyronine,FT3)与四肢肌肉质量(appendicular muscle mass,ASM)呈正相关(P=0.003),校正年龄、性别及体重指数(body mass index,BMI)后二者间仍存在正相关性(P=0.011);FT3与总肌肉量(去除头部)呈正相关(P=0.024),校正年龄、性别及BMI后仅发现女性入组者中二者仍呈正相关,而男性中未见明显相关;促甲状腺激素(thyroid stimulating hormone,TSH)与四肢脂肪含量、总脂肪量(去除头部)呈负相关(P=0.039;P=0.038),校正混杂因素后并未发现明显相关性。结论:甲状腺功能正常的老龄人群中甲状腺激素水平影响身体成分。
[Abstract]:Objective: to explore the relationship between thyroid hormone and muscle and fat in aged people. Methods: 74 healthy people aged more than 60 years old with normal thyroid function were enrolled in this study. The average age was 74.6 卤7.7 years old. The body weight, thyroid function and body composition were measured. Results: free triiodothyronine free triiodothyronine. FT3 was positively correlated with appendical muscle mass (ASM) and corrected age. There was still a positive correlation between gender and body mass index (BMI) after body mass index (BMI). There was a positive correlation between FT3 and total muscle volume (removing head). After adjusting for age, sex and BMI, it was found that there was still a positive correlation between FT3 and total muscle volume (removing head), but no significant correlation was found in males. There was a negative correlation between thyroid-stimulating hormone (stimulating) and limb fat content and total fat content (head removal). There was no obvious correlation after adjusting for the confounding factors. Conclusion: the thyroid hormone level affects the body composition in the elderly with normal thyroid function.
【作者单位】：南京医科大学第一附属医院内分泌科;南京医科大学第一附属医院老年内分泌科;
【基金】：国家自然科学基金(81670724,91649122)
【分类号】：R446.1
【正文快照】： 骨骼肌是甲状腺激素的重要靶器官,甲状腺激素通过骨骼肌特异性受体(三碘甲状腺原氨酸受体,T3受体)及其受体后效应,调节着脂肪、蛋白质和糖等三大物质代谢,因此甲状腺激素对能量代谢及身体成分有着深远影响。已发现,甲状腺机能减退(甲减)时可出现体重增加,而甲状腺机能亢进(

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